کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937689 1475319 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A possible role of dystrophin in neuronal excitability: A review of the current literature
ترجمه فارسی عنوان
نقش احتمالی دیستروفین در تحریک پذیری عصبی: یک مرور از ادبیات فعلی؟
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• Epilepsy is more frequently observed in muscular dystrophy (MD) populations.
• Initial experimental research confirms altered levels of dystrophin in epilepsy.
• Seizure generation thresholds seem to be different in animal models of MD.
• A lack of dystrophin in the CNS might contribute to hyperexcitation.

Duchenne muscular dystrophy (DMD) is a recessive hereditary form of muscular dystrophy caused by a mutation in the dystrophin gene on the X chromosome. Clinical observations show that in addition to progressive muscular degeneration, DMD is more often accompanied by neurocognitive symptoms and learning disabilities, especially in automatisation of reading, attention processes, and expressive language skills. Additionally, three studies reported a higher prevalence of epilepsy in DMD, suggesting that the absence of dystrophin might be related to increased CNS excitability. In this article, we aim to review current clinical and experimental evidence for a potential role of brain dystrophin in seizure generation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 51, April 2015, Pages 255–262
نویسندگان
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