کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937713 1475329 2014 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The trouble with circadian clock dysfunction: Multiple deleterious effects on the brain and body
ترجمه فارسی عنوان
مشکل با اختلال عملکرد ساعت دیجیتال: اثرات مضر متعدد بر روی مغز و بدن
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


• Outlines the relationship between circadian disruption and various diseases.
• Summarizes evidence from animal models of circadian disruption and disease.
• Summarizes neurobiological changes associated with circadian disruption.

This review consolidates research employing human correlational and experimental work across brain and body with experimental animal models to provide a more complete representation of how circadian rhythms influence almost all aspects of life. In doing so, we will cover the morphological and biochemical pathways responsible for rhythm generation as well as interactions between these systems and others (e.g., stress, feeding, reproduction). The effects of circadian disruption on the health of humans, including time of day effects, cognitive sequelae, dementia, Alzheimer's disease, diet, obesity, food preferences, mood disorders, and cancer will also be discussed. Subsequently, experimental support for these largely correlational human studies conducted in non-human animal models will be described.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 40, March 2014, Pages 80–101
نویسندگان
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