کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
937952 924562 2011 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cognitive evoked potentials in narcolepsy: A review of the literature
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Cognitive evoked potentials in narcolepsy: A review of the literature
چکیده انگلیسی

Subtle cognitive deficits have been described in narcolepsy. They have been hypothesised to be related to changes in the hypocretin system. Event-related potential (ERP) paradigms are known to be useful tools in the investigation of information processing and seem to be sensitive to subtle neuropsychological changes. We review empirical articles on ERPs in narcolepsy in order to contribute to clarify the pattern of cognitive deficits that are specific to this disease and, possibly, to identify specific cognitive domains that improve with treatment. Fourteen peer-reviewed articles were selected for this review. These studies were conducted with passive and active oddball paradigms and support the existence of changes in cognitive attentive processing in narcolepsy, possibly in association with altered functioning of the prefrontal cortex. ERP low-resolution electromagnetic tomography revealed that modafinil improved information processing speed and increased energetic resources in prefrontal cortical areas. These findings suggest that it is worthwhile to further evaluate the usefulness of ERPs in the detection of cognitive dysfunction in this disorder before and after treatment.

Research highlights▶ Subtle cognitive impairment might accompany sleep disturbance in narcolepsy. ▶ An executive control deficit has been shown in narcolepsy. ▶ ERPs are high temporal resolution techniques which may contribute to the assessment of subtle cognitive dysfunction in narcoleptic patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 35, Issue 5, April 2011, Pages 1144–1153
نویسندگان
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