Comorbidity of bipolar and eating disorders: distinct or related disorders with shared dysregulations?

Nonetheless, the reviewed literature leaves little doubt that bipolar and eating disorders - particularly bulimia nervosa and bipolar II disorder - are related. Although several antidepressants and mood stabilizers have shown promise for eating disorders, their clinical use when these disorders co-exist with bipolarity is still very much of an art. We trust that this review will stimulate more rigorous research in their shared putative underlying psychobiologic mechanisms which, in turn, could lead to more rational targeted treatments.