Mood, cognition and EEG changes during interferon α (alpha-IFN) treatment for chronic hepatitis C

α-IFN treatment caused a time-dependent induction of symptoms of mild depression, concurrent anxiety and EEG changes. These psychiatric and neurophysiological changes can better explain the pharmacological profile of α-IFN and could help to address research on at risk population and, particularly, during pegylated-IFN therapy.