کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
938131 924585 2010 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of antihistaminic effects in the misuse of quetiapine: A case report and review of the literature
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
The role of antihistaminic effects in the misuse of quetiapine: A case report and review of the literature
چکیده انگلیسی

Recent case reports and case series suggest that the atypical antipsychotic quetiapine has the potential for misuse. This includes drug-seeking behaviors motivated by quetiapine as well as inappropriate (intranasal or intravenous) administration. We present an additional case of quetiapine misuse and review other published cases. In general, quetiapine misuse is associated with prior CNS depressant use and is more common in forensic settings. The mechanism of reinforcement for this misuse is unknown, but we hypothesize that it is related to quetiapine's pharmacological profile as an antihistamine with a relative low affinity for dopamine receptors. The risks to individuals and society of exaggerating/simulating symptoms to obtain high-dose quetiapine in the absence of a clinical indication are discussed. This includes the unwelcome possibility of restricting access to this effective medication.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 34, Issue 4, March 2010, Pages 555–558
نویسندگان
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