کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
938139 | 1475332 | 2006 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Long-term cognitive sequelae of antenatal maternal anxiety: involvement of the orbitofrontal cortex Long-term cognitive sequelae of antenatal maternal anxiety: involvement of the orbitofrontal cortex](/preview/png/938139.png)
Anxiety and stress experienced by the mother during pregnancy are reported to have a negative association with the cognitive development of the child. An integration of recent evidence from cognitive reaction time tasks pointed to a deficit in endogenous response inhibition, a function ascribed to prefrontal cortex. To further delineate the cognitive sequelae associated with antenatal maternal anxiety, we reviewed recent neuro-imaging literature to create a cortical map of regions commonly and selectively activated by well-known cognitive tasks. The pragmatic value of this cortical map was tested in a follow-up sample of 49 17-year old adolescents. Adolescents of mothers with high levels of anxiety during week 12–22 of their pregnancy performed significantly lower in tasks which required integration and control of different task parameters. Working memory, inhibition of a prepotent response, and visual orienting of attention were not impaired. Based on the established cortical map, these results were related to subtle developmental aberrations in a part of, or in cortical and sub-cortical regions linked to, the orbitofrontal cortex.
Journal: Neuroscience & Biobehavioral Reviews - Volume 30, Issue 8, 2006, Pages 1078–1086