کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
938158 | 924588 | 2006 | 20 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response Relationship of the predatory attack experience to neural plasticity, pCREB expression and neuroendocrine response](/preview/png/938158.png)
Aggression takes at least two, an attacker and a target. This paper will address the lasting consequences of being a target of aggression. We review the lasting impact of predatory attack on brain and behavior in rodents. A single brief unprotected exposure of a rat to a cat lastingly alters affective responses of rats in a variety of contexts. Alterations of these behaviors resembles both generalized anxiety comorbid with post traumatic stress disorder (PTSD), and the hyper arousal expressed in enhanced startle in PTSD. Examination of neural transmission and neural plasticity in limbic circuits implicates changes in transmission in two connecting pathways in many but not all of the behavioral changes. Quantification of the predator encounter reveals that both the behavior of the predator and the reaction of the rat to attack are highly predictive of the effects of predatory attack on molecular biological (pCREB expression) and electrophysiological measures of limbic neuroplastic change. Moreover, a case will be made that the pattern of change of corticosteroid level over three hours after the predator encounter, in interaction with the predatory experience, plays an important part in initiation of lasting changes in brain and behavior.
Journal: Neuroscience & Biobehavioral Reviews - Volume 30, Issue 3, 2006, Pages 356–375