کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9385359 | 1280507 | 2005 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Overrepresentation of immunostimulatory CpG motifs in Burkholderia genomes
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Overrepresentation of immunostimulatory CpG motifs in Burkholderia genomes Overrepresentation of immunostimulatory CpG motifs in Burkholderia genomes](/preview/png/9385359.png)
چکیده انگلیسی
Pulmonary infections with Burkholderia cepacia complex organisms contribute significantly to morbidity and mortality in patients with cystic fibrosis (CF), partially due to the intense inflammatory response of the host to the presence of bacteria and their byproducts. In the present study we show that Burkholderia genomes contain a large number of immunostimulatory CpG motifs. This is mainly because of their large genome size. This suggests that DNA from Burkholderia sp. has the potential to cause significant inflammatory response. Whether this contributes significantly to the airway inflammation often observed in infected CF patients remains to be determined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 4, Issue 3, September 2005, Pages 193-196
Journal: Journal of Cystic Fibrosis - Volume 4, Issue 3, September 2005, Pages 193-196
نویسندگان
Tom Coenye, Peter Vandamme,