Characterization of Circulating Monocytes Expressing HLA-DR or CD71 and Related Soluble Factors for 2 Weeks after Severe, Non-Thermal Injury1,2

Altered proportions of monocytes expressing HLA-DR and CD71 and elevated sCD14 and urine neopterin levels, for up to 2 weeks after severe injury, underscores an extended period of profound immunological effects. Additional studies to more fully assess temporal monocyte response patterns after severe injury, including activation, may be warranted.