Effects of Cyclophilin A on Myeloblastic Cell Line KG-1 Derived Dendritic Like Cells (DLC) Through p38 MAP Kinase Activation1,2

CypA enhances DC differentiation and maturation by up-regulating CD11b and CD11c expression. CypA can also augment DC antigen uptake and antigen presentation, which may be mediated by the p38 signaling pathway.