Angiotensin Converting Enzyme-Independent Angiotensin II Production by Chymase is Up-regulated in the Ischemic Kidney in Renovascular Hypertension

Chymase activity is up-regulated in the ischemic kidney of 2K1C rats. Plasma ANG II does not appear to regulate intrarenal chymase activity, suggesting that ischemia per se up-regulates chymase activity in the kidney. ACE-independent ANG II production by chymase may provide a mechanism for augmenting intrarenal ANG II in the ischemic kidney in RVH.