کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9402684 1288549 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Prolonged exposure of canine coronary arteries to a nitric oxide donor desensitizes soluble guanylate cyclase
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی عمل جراحی
پیش نمایش صفحه اول مقاله
Prolonged exposure of canine coronary arteries to a nitric oxide donor desensitizes soluble guanylate cyclase
چکیده انگلیسی
Prolonged exposure of coronary arteries to SNP did not alter vascular smooth muscle function, but it markedly attenuated the relaxation in response to both A23187 and authentic NO at concentrations above 10−9 M in a concentration-dependent fashion. The constant levels of cGMP in response to an NO donor suggest that the attenuation of relaxation is due to desensitization of soluble guanylate cyclase. Thus, this study supports the role of soluble guanylate cyclase desensitization in the development of tolerance to organic nitrates.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Surgical Research - Volume 123, Issue 1, January 2005, Pages 82-88
نویسندگان
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