کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9406582 | 1290130 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Involvement of dopamine receptors in cocaine-induced genital reflexes after paradoxical sleep deprivation
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
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چکیده انگلیسی
Previous work has demonstrated that paradoxical sleep deprivation (PSD) potentiates cocaine-induced genital reflexes in male rats. To examine the possibility that this effect might involve alterations in binding to the DA transporter (DAT), we examined [3H] WIN 35,248 binding in brain after 96Â h of PSD. No changes were found in any of the 11 brain regions examined. Since we had previously identified changes in D2 receptor binding after PSD, we next examined the effects of DA receptor subtype antagonists on cocaine-induced reflexes in sleep-deprived rats. Separate groups of PSD rats received saline, haloperidol (0.4, 0.8 or 1.6Â mg/kg), SCH 23390 (0.25, 0.5, 1Â mg/kg) or sulpiride (50, 100, 200Â mg/kg) 60Â min prior to acute cocaine (7Â mg/kg). In saline pretreated rats, cocaine-induced penile erection (PE) in 100% of SD rats. This percentage was not significantly reduced by haloperidol at any dose, but was significantly reduced in rats pretreated with SCH 23390 (1Â mg/kg) or sulpiride (100 or 200Â mg/kg). In addition, acute cocaine-induced ejaculation in 80% of SD rats. This effect was not affected by haloperidol at any dose, but was significantly reduced by all doses of SCH 23390 and by the 200Â mg/kg dose of sulpiride. These results suggest that the potentiating effects of cocaine on penile erection and ejaculation are likely due to PSD-induced changes in DA postsynaptic receptor sensitivity rather than alterations in DA transporter. They further suggest that both D1 and D2 receptors may play a role in these effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 160, Issue 1, 7 May 2005, Pages 44-50
Journal: Behavioural Brain Research - Volume 160, Issue 1, 7 May 2005, Pages 44-50
نویسندگان
Monica Levy Andersen, Ligia Assumpção Papale, Débora Cristina Hipólide, José N. Nobrega, Sergio Tufik,