کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410544 | 1613316 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Steroid-induced alterations in mRNA expression of the long form of the prolactin receptor in the medial preoptic area of female rats: Effects of exposure to a pregnancy-like regimen of progesterone and estradiol
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Steroid-induced alterations in mRNA expression of the long form of the prolactin receptor in the medial preoptic area of female rats: Effects of exposure to a pregnancy-like regimen of progesterone and estradiol Steroid-induced alterations in mRNA expression of the long form of the prolactin receptor in the medial preoptic area of female rats: Effects of exposure to a pregnancy-like regimen of progesterone and estradiol](/preview/png/9410544.png)
چکیده انگلیسی
It is firmly established that the onset of maternal behavior in the female rat is stimulated by a combination of hormones that include prolactin (PRL), estradiol (E2), and progesterone (P4). Specifically, nulliparous rats display short latencies to respond to foster young when primed with Silastic capsules filled with P4 and E2 and then administered PRL centrally to the medial preoptic area (MPOA), an area integrally involved in the expression of maternal behavior in this species. PRL or P4 treatments alone are ineffective in stimulating the expression of maternal care. Since the actions of PRL in the MPOA appear to be mediated by PRL receptors, it was of interest to determine whether and how treatment with P4 and E2 together or separately might alter mRNA expression of the long form of the PRL receptor (PRL-RL) in the MPOA. Using in situ hybridization histochemistry (ISHH), mRNA expression of the PRL-RL was measured in the MPOA of ovariectomized, nulliparous rats treated with various combinations of P4 and E2. Treatment of animals with P4 alone for 10 days or with P4 followed by E2 for 1 or 4 days resulted in reductions in PRL receptor mRNA expression in the MPOA when compared with the expression in animals treated with E2 alone or blank capsules. The actions of P4 on mRNA expression of the PRL-RL were more pronounced in the dorsal MPOA. Circulating PRL levels collected at the time of sacrifice were elevated in all groups treated with E2, but no association between PRL levels and receptor mRNA expression within the MPOA was evident. These findings indicate that the dorsal MPOA may be one site of progesterone's action in facilitating prolactin-mediated maternal behavior.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 140, Issues 1â2, 31 October 2005, Pages 10-16
Journal: Molecular Brain Research - Volume 140, Issues 1â2, 31 October 2005, Pages 10-16
نویسندگان
Robert S. Bridges, Linda E. Hays,