کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410613 | 1291268 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine
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کلمات کلیدی
Gene transfection - انتقال ژنβ-galactosidase - بتا گالاکتوزیدازParkinson's disease - بیماری پارکینسونsubstantia nigra - توده سیاهDevelopment and regeneration - توسعه و بازسازیNeurotrophic factors: receptors and cellular mechanisms - عوامل نوروئیدی: گیرنده ها و مکانیسم های سلولیHerpes simplex virus-1 - ویروس هرپس سیمپلکس 1polyethyleneimine - پلی اتیلنیمینfibroblast growth factor receptor - گیرنده فاکتور رشد فیبروبلاست
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine Transfection of tyrosine kinase deleted FGF receptor-1 into rat brain substantia nigra reduces the number of tyrosine hydroxylase expressing neurons and decreases concentration levels of striatal dopamine](/preview/png/9410613.png)
چکیده انگلیسی
The effects of HSV-1 amplicon and polyethyleneimine (PEI)-mediated transfection of dominant negative FGF receptor-1 mutant FGFR1(TKâ) into the rat brain substantia nigra (SN) were examined in vivo to model the reduced FGF signaling documented to occur in Parkinson's disease. The number of SN neurons that expressed tyrosine hydroxylase (TH) was significantly reduced following HSV-1 FGFR1(TKâ) intranigral delivery and similar changes were observed after PEI-mediated FGFR1(TKâ) transfections. Further, we also observed a significantly lower striatal dopamine content following the PEI transfection of FGFR1(TKâ). Thus, we conclude that reduced FGF signaling in the SN of Parkinsonian patients could play a role in the impaired dopaminergic transmission associated with the degenerative disease.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 139, Issue 2, 3 October 2005, Pages 361-366
Journal: Molecular Brain Research - Volume 139, Issue 2, 3 October 2005, Pages 361-366
نویسندگان
Thomas D. Corso, German Torres, Christopher Goulah, Indrajit Roy, Angelo S. Gambino, John Nayda, Timothy Buckley, Ewa K. Stachowiak, Earl J. Bergey, Haridas Pudavar, Purnendu Dutta, David C. Bloom, William J. Bowers, Michal K. Stachowiak,