کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9410783 1613317 2005 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Expression of BLT1 leukotriene B4 receptor on the dorsal root ganglion neurons in mice
چکیده انگلیسی
We investigated using mice whether dorsal root ganglion (DRG) neurons express leukotriene B4 receptors. BLT1, but not BLT2, receptor mRNA was expressed in the DRG. Leukotriene B4 increased intracellular Ca2+ concentration in cultured DRG neurons, which was inhibited by leukotriene B4 antagonist. Many BLT1-immunoreactive neurons were small in size and positive for TRPV1. BLT1-immunoreactive fibers are present in the skin. The results suggest the expression of functional BLT1 receptors in the sensory neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 137, Issues 1–2, 13 June 2005, Pages 263-266
نویسندگان
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