کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9410860 1291277 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Multiple 5′-splice variants of the rat glutamate transporter-1
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Multiple 5′-splice variants of the rat glutamate transporter-1
چکیده انگلیسی
In most brain areas, uptake of extracellular glutamate predominantly occurs through the glutamate transporter subtype, glutamate transporter-1 (GLT-1), which is enriched in astroglia. Here, we report the identification of five splice variants of the 5′-leader sequence of rat GLT-1 which contain varying numbers of upstream open reading frames and encode putative GLT-1 proteins with two distinct N-terminal modifications. We further demonstrate that the identified rat 5′-GLT-1 splice variants are expressed in a brain region-specific manner. Our findings point to potential influences of RNA splicing on glial glutamate transport in the intact and injured rat brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 133, Issue 1, 5 January 2005, Pages 157-161
نویسندگان
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