کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410915 | 1613318 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system
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کلمات کلیدی
Neurotransmitters, Modulators, Transporters, and Receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاtyrosine hydroxylase - تیروزین هیدروکسیلازRegional localization of receptors and transmitters - محلی سازی گیرنده ها و فرستنده هاPostmortem human brain - مغز انسان پس از قاعدگیMelatonin - ملاتونینD2 receptor - گیرنده D2
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system The regional and cellular expression profile of the melatonin receptor MT1 in the central dopaminergic system](/preview/png/9410915.png)
چکیده انگلیسی
The physiological effects of pineal melatonin are primarily mediated by melatonin receptors located in the brain and periphery. Even though there are a number of studies demonstrating the regulatory role of melatonin in the development of dopaminergic behaviors, such as psychostimulant-induced diurnal locomotor sensitization or drug seeking, little is known about the contribution of melatonin receptors (i.e., MT1) to this role. Therefore, as a first step in understanding the functional role of melatonin receptors in dopaminergic behaviors, we focused on determining the expression pattern of MT1 receptors in the dopaminergic system of the human and rodent brain. Regional (e.g., nucleus accumbens shell) and cellular (e.g., tyrosine hydroxylase immunopositive cells) expression of MT1 mRNA was characterized by applying the immuno-laser capture microdissection (immuno-LCM) technique coupled with nested RT-PCR. Moreover, employing quantitative Western immunoblotting and RT-PCR, we found that the mouse MT1 receptor expression presents diurnal variations (i.e., low mRNA and high protein levels at night, ZT21). The dopaminergic system-based presence of MT1 receptor proteins was not limited to rodents; we found these receptors in postmortem human brain as well. Further research is needed to understand the regional/cellular functional role of melatonin receptors in the regulation of dopaminergic behaviors, using models such as melatonin receptor knockout mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 136, Issues 1â2, 20 May 2005, Pages 45-53
Journal: Molecular Brain Research - Volume 136, Issues 1â2, 20 May 2005, Pages 45-53
نویسندگان
Tolga Uz, Ahmet D. Arslan, Murat Kurtuncu, Marta Imbesi, Mustafa Akhisaroglu, Yogesh Dwivedi, Ghanshyam N. Pandey, Hari Manev,