کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9410920 | 1613318 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
TRPM8 protein localization in trigeminal ganglion and taste papillae
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کلمات کلیدی
TRPM8Neurotransmitters, Modulators, Transporters, and Receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاImmunohistochemistry - ایمونوهیستوشیمیlingual nerve - عصب زبانیRegional localization of receptors and transmitters - محلی سازی گیرنده ها و فرستنده هاThermosensitive neuron - نورون ترم حساسFungiform papilla - پاپیون قارچtrigeminal ganglion - گانگلیون سه گانه
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: TRPM8 protein localization in trigeminal ganglion and taste papillae TRPM8 protein localization in trigeminal ganglion and taste papillae](/preview/png/9410920.png)
چکیده انگلیسی
TRPM8 is a TRP family cation channel which can be activated by cold stimuli or l-menthol. However, TRPM8 protein localization of nerve terminals in sensory organs remains unknown. Here we generated an antibody against TRPM8 and analyzed TRPM8 protein localization in trigeminal ganglia (TG) and in sensory nerve fibers in the tongue. TRPM8 immunoreactivity was detected in a subset of neurons with a small diameter in TG and in nerve fibers in the tongue. TRPM8-immunoreactive nerve fibers were rich in fungiform papillae, but sparse in foliate and circumvallate papillae. The TRPM8-immunoreactive nerve fibers reached the outer epithelial layer in each papilla, while no TRPM8-immunoreactive nerve fibers penetrated into taste buds. Double labeling analysis revealed that TRPM8 immunoreactivity was co-expressed with a part of TRPV1 or CGRP-immunoreactive neurons in TG. However, TRPM8 immunoreactivity was not observed in TRPV1- or CGRP-positive nerve fibers in fungiform, foliate, and circumvallate papillae. These results suggest that TRPM8 protein is present in sensory lingual nerve fibers mainly projected from TG and might work as cold and l-menthol receptors on tongue.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 136, Issues 1â2, 20 May 2005, Pages 91-98
Journal: Molecular Brain Research - Volume 136, Issues 1â2, 20 May 2005, Pages 91-98
نویسندگان
Junji Abe, Hiroshi Hosokawa, Makoto Okazawa, Mikako Kandachi, Yosuke Sawada, Keiji Yamanaka, Kiyoshi Matsumura, Shigeo Kobayashi,