کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9410935 1613318 2005 24 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
Gene expression profiling during the embryonic development of mouse brain using an oligonucleotide-based microarray system
چکیده انگلیسی
We analyzed gene expression profiles in embryonic day 12, 15, 18 and postnatal day 0 mouse brains by utilizing a GeneChip microarray. Significant differential expression was observed in 1413 of 12,422 (11.4%) represented on the chip. Then, 397 genes known to be related to neural development and functions were selected and analyzed in more detail. Clustering of the differentially expressed genes in terms of gene function and their temporal expression patterns indicated an aspect of the genetic foundation that underlies cellular events. Moreover, we identified a novel gene that encodes a putative protein kinase, Ebr kinase, which is differentially expressed in the developing brain.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Brain Research - Volume 136, Issues 1–2, 20 May 2005, Pages 231-254
نویسندگان
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