Effects of prenatal stress on anxiety and social interactions in adult rats

Deficits in social behavior are found in several neuro-psychiatric disorders with a presumed developmental origin. The aim of the present study is to determine if prenatal stress at a given day of gestation alters social behavior in adult offspring. Pregnant rats were exposed to an acute stress (presence of a cat) either at the 10th (S10), the 14th (S14) or the 19th (S19) gestational day. When adult, their offsprings were studied in anxiety, neophobic and social behaviors. The results showed that S10 and S19 rats were more anxious and less aggressive than control rats, while the anxious and aggressive behavior of S14 rats was similar to that of the control ones. It is suggested that day 14 of pregnancy is a hyposensitive period to stressful agents due to an important plasticity of the developing gross nervous structures.