کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9414571 | 1292047 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Postnatal handling does not normalize hypothalamic corticotropin-releasing factor mRNA levels in animals prenatally exposed to ethanol
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کلمات کلیدی
CRFparvocellular paraventricular nucleusACTHpPVNmRNAAVPadrenocorticotropin - آدرنوکورتیکوتروپینpair-fed - جفت خوردهmessenger ribonucleic acid - رسوب ریبونوکلئیک اسیدcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینPrenatal ethanol exposure - قرار گرفتن در معرض اتانول پیش از قاعدگیNeural Basis of Behavior - مبانی عصبی رفتاریPostnatal handling - مدیریت پس از زایمانDrugs of abuse: alcohol, barbiturates, and benzodiazepines - مواد مخدر: الکل، باربیتورات ها و بنزودیازپین هاHPA - میلی بار یا هکتوپاسکالhypothalamic–pituitary–adrenal - هیپوتالاموس-هیپوفیز-آدرنالarginine vasopressin - وازوپرسین آرژینینCORT - کورتCorticosterone - کورتیکوسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب تکاملی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Postnatal handling has been shown to attenuate some of the deficits in developmental outcome observed following prenatal ethanol exposure (E) although it appears to be ineffective at ameliorating the hypothalamic-pituitary-adrenal (HPA) hyperresponsiveness to stressors that has been observed in adult E animals. However, the effects of postnatal handling on central regulation of HPA activity in E animals, particularly with regard to alterations in steady-state hypothalamic corticotropin-releasing factor (CRF) activity, have not been examined. In the present study, offspring from E, pair-fed (PF), and ad-libitum-fed control (C) groups were exposed to daily handling during the first 2 weeks of life (H) or were left entirely undisturbed until weaning (NH). Basal CRF and arginine vasopressin (AVP) mRNA in the parvocellular portion of the paraventricular nucleus (pPVN) of the hypothalamus were assessed at 90-110 days of age. Prenatal ethanol exposure resulted in elevated basal pPVN CRF mRNA levels compared to those in ad-libitum-fed controls. Handling altered CRF mRNA levels in a sex-specific and prenatal treatment-specific manner. Females showed no significant effects of handling. In contrast, handling decreased CRF mRNA levels in PF and C but not E males compared to their NH counterparts. There were no effects of prenatal ethanol or postnatal handling on AVP mRNA levels. These findings indicate that prenatal ethanol exposure results in elevated basal CRF mRNA levels in adulthood and that handling appears to be ineffective in normalizing those elevations, supporting the suggestion that altered basal HPA regulation in E animals may, at least in part, underlie their HPA hyperresponsiveness to stressors.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Brain Research - Volume 157, Issue 1, 9 June 2005, Pages 74-82
Journal: Developmental Brain Research - Volume 157, Issue 1, 9 June 2005, Pages 74-82
نویسندگان
Kara I. Gabriel, Maria M. Glavas, Linda Ellis, Joanne Weinberg,