کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415693 | 1614321 | 2005 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Exercise affects glutamate receptors in postsynaptic densities from cortical mice brain
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کلمات کلیدی
postsynaptic density protein of 95 kDaPSDAMPAGRIP-1NMDAN-methyl-d-aspartatePSD-95glutamate receptor interacting protein 1GluR1MAGUK - آنهاpostsynaptic density - تراکم PostinapticExcitable membranes and synaptic transmission - غشاء جذاب و انتقال سیناپسیPhosphorylation - فسفریلاسیونBrain - مغزPostsynaptic mechanisms - مکانیزم های پستVoluntary exercise - ورزش داوطلبانهGlutamate receptor - گیرنده گلومات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Physical activity has been proposed as a behavior intervention that promotes mental health and some of the benefits induced by exercise have been related to the glutamatergic system. Indeed, glutamate is the most abundant excitatory neurotransmitter in brain. Thus, we evaluated if voluntary exercise in mice could modulate glutamatergic synapses at level of postsynaptic density (PSD). Through Western blot, we found that exercise during 1 month increased glutamatergic-related protein content in PSD from cortex of mice. Exercise increased the immunocontent of GluR1 (129%), SAP-97 (179%), GRIP-1 (129%), and in less extent, GluR2/3 (118%) and PSD-95 (112%) proteins. The overall content of NMDA subunits R1, R2A and R2B were not altered in mice that had exercised, however, the phosphorylated NMDA subunits, phospho-NMDAR1 (150%), and phospho-NMDAR2B (183%) showed a strong increase. Because exercise increased the content of phosphorylated forms of NMDA receptors, we evaluated the binding of MK-801, a specific ligand that binds to open NMDA channel. Exercise increased the binding of MK-801 in cortical cellular membranes in 51%. Altogether, our results point to a modulation of glutamatergic synapses by exercise with likely implications in the exercise-induced mental health.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1065, Issues 1â2, 14 December 2005, Pages 20-25
Journal: Brain Research - Volume 1065, Issues 1â2, 14 December 2005, Pages 20-25
نویسندگان
Marcelo O. Dietrich, Carlos E. Mantese, Lisiane O. Porciuncula, Gabriele Ghisleni, Lúcia Vinade, Diogo O. Souza, Luis V. Portela,