Keywords: Spines; PSD-95; AMPA receptor; Learning and memory; Aging; Hippocampus;
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Keywords: Cytoarchitecture; Hippocampal neuron; Immunocytochemistry; RNA-seq; Stigmasterol; Transcriptomics; ACBN; axonal collateral branch number; ACBPN; axonal collateral branch point number; ACBT; axonal collateral branch points tip; CNS; Central nervous system;
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; α-SMA; alpha- smooth muscle actin; BBB; blood-brain barrier; BDNF; brain derived neurotrophic factor; bFGF or FGF2; basic fibroblast growth factor; BrdU; bromodeoxyuridine; CIMT; const
Keywords: AD; Alzheimer's disease; BBB; blood brain barrier; RAGE; Receptor for Advanced Glycation End products; AGE; advanced glycation end products; IL1β; interleukin 1 beta; Aβ; amyloid beta; TNF â;  tumor necrosis factor alpha; TGFβ; transforming growth
Keywords: Schizophrenia; Atypical antipsychotic; Brain imaging; Shank; PSD-95;
Keywords: Traumatic brain injury; Chronic traumatic encephalopathy; Tauopathy; Concussion; Repetitive head injury; 2-AG; 2-arachidonoylglycerol; 3-NT; 3-nitrotyrosine; 4-HNE; 4-hydroxynonenal; Ach; acetylcholine; AChEI; acetylcholine esterase inhibitor; AD; Alzheim
Keywords: Lead exposure; Neurotoxicity; Lipid peroxide; Apoptosis; TNFα; PSD-95; SNAP-25; BDNF; TrkB; VAChT
Keywords: PD; Parkinson's disease; MPTP; 1-methyl-4-phenyl-l,2,3,6-tetrahydropyridine; TH; tyrosine hydroxylase; PSD-95; post-synaptic density protein 95; SNpc; substantia nigra pars compacta; Parkinson's disease; Exercise; Synapse; Dendritic spine;
Keywords: BBB; blood-brain barrier; BSA; bovine serum albumin; cAMP; cyclic adenosine monophosphate; CGRP; calcitonin gene-related peptide; CHO; Chinese hamster ovary; CLR; calcitonin receptor-like receptor; CNS; central nervous system; DAB; 3,3â²-diaminobenzidi
Keywords: Schizophrenia; Synapse; Olfactory bulb; Synaptophysin; SNAP-25; PSD-95;
Keywords: Nanotoxicity; PSD-95; Synapsin I; Synaptophysin; Myelin-like bodies
Keywords: GFAP; PSD-95; Spinophilin; CA1; Macaca fascicularis;
Keywords: Aβ amyloid; Aging; Alzheimer's disease; Cell viability; Cell death; Cerebral cortex; Cortical layers; Cortical vulnerability; Cux2; Kainic acid; Okadaic acid; PSD-95;
Keywords: ACC; anterior cingulate cortex; AMPA; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; ANOVA; One-Way Analysis of Variance; CAb; core of the nucleus accumbens; CREB; Ca++ Responsive Element Binding Protein; D1R; dopamine D1 receptor; D2R; dopamine D
Keywords: AD; Alzheimer's disease; Aβ; amyloid-beta peptide; BSA; bovine serum albumin; CSF; cerebrospinal fluid; CM-H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DMSO; dimethylsulfoxide; DTT; dithiothreitol; D-PBS; Dulbecco's phosphate-buffered saline;
Keywords: mPFC; medial prefrontal cortex; ACC; anterior cingulate cortex; DG; dentate gyrus; NAc; nucleus accumbens; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor; NMDAR; N-methyl-d-aspartic acid receptor; VDCC; voltage-dependent calcium ch
Keywords: Medial prefrontal cortex: adolescence; Social isolation; PSD-95; c-fos; Arc
Ketamine promotes rapid and transient activation of AMPA receptor-mediated synaptic transmission in the dorsal raphe nucleus
Keywords: ACSF; Artificial cerebrospinal fluid; D-AP5; [D-(-)-2-Amino-5-phosphonopentanoic acid]; DMSO; Dimethyl sulfoxide; DNQX; [6,7-Dinitroquinoxaline-2,3-dione]; DR; Dorsal raphe nucleus; MK-801; [(5S,10R)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5
Ketamine-induced hypnosis and neuroplasticity in mice is associated with disrupted p-MEK/p-ERK sequential activation and sustained upregulation of survival p-FADD in brain cortex: Involvement of GABAA receptor
Keywords: Ketamine; Hypnosis; Neuroplasticity; MEK-ERK; FADD; NF-kB; Mouse brain; CNS; central nervous system; Elk-1; nuclear substrate belonging to the family of ETS domain-containing transcription factors; ERK; extracellular signal-regulated kinase; FADD; Fas-ass
PSD95: A synaptic protein implicated in schizophrenia or autism?
Keywords: Neurodevelopment; Glutamate; PSD-95; NMDAR; AMPAR; Schizophrenia; Autism;
Stress-induced hippocampus Npas4 mRNA expression relates to specific psychophysiological patterns of stress response
Keywords: AdorA1; adenosine receptor A1; ANOVA; analysis of variance; Arbp; ribosomal protein large P0; AID; activity-regulated inhibitor of death; Arc; activity-regulated cytoskeleton; Bcl2; B-cell lymphoma 2; Bdnf; brain-derived neurotrophic factor; c-fos; FBJ os
Auxiliary subunits of AMPA receptors: The discovery of a forebrain-selective antagonist, LY3130481/CERC-611
Keywords: ABHD6; alpha/beta-hydrolase domain-containing protein 6; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; CKAMP; cystine-knot AMPAR modulating protein; CNIH; cornichon; CPT1c; carnitine palmitoyltransferase 1C; FRRS1L; ferric chelate reductase 1-
Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS
Keywords: CNS; central nervous system; NPAS3; neuronal per-arnt-sim domain protein 3; NMD; nonsense-mediated mRNA decay; PTBP; polypyrimidine tract binding proteins; PSD-95; postsynaptic density-95; TDP-43; TAR DNA-binding protein-43; qPCR; quantitative real-time P
PTK2B/Pyk2 overexpression improves a mouse model of Alzheimer's disease
Keywords: Alzheimer's disease; Mouse model; Non-receptor tyrosine protein kinase; Pyk2; Src; 5XFAD; mice transgenic for human APP and presenilin1 with 5 mutations found in familial Alzheimer's disease; AAV; adeno-associated virus; Aβ; amyloid β; AD; Alzheimer's d
Chronic infusion of Wnt7a, Wnt5a and Dkk-1 in the adult hippocampus induces structural synaptic changes and modifies anxiety and memory performance
Keywords: Anxiety; Bassoon; Memory; PSD-95; Synapses; Tau phosphorylation; Wnt signaling;
Methamphetamine augment HIV-1 Tat mediated memory deficits by altering the expression of synaptic proteins and neurotrophic factors
Keywords: HIV-1 Tat; Methamphetamine; Memory deficits; Synapsin1; PSD-95; BDNF; p-CaMKII;
Calcium as a Trojan horse in mental diseases-The role of PMCA and PMCA-interacting proteins in bipolar disorder and schizophrenia
Keywords: BD; bipolar disorder; CaM; calmodulin; CaN; calcineurin; ER; endoplasmic reticulum; GABA; γ-aminobutyric acid; GAP-43; growth associated protein 43; NCKX; Na+/Ca2+-K+ exchanger; NCX; Na+/Ca2+ exchanger; PIP2; phosphatidylinositol 4,5-bisphosphate; PMCA;
Increased Neuroligin 2 Levels in the Postsynaptic Membrane in Spinal Dorsal Horn may Contribute to Postoperative Pain
Keywords: AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole propionate; CPS; cumulative pain score; PSD-95; postsynaptic density protein 95; PWT; paw withdrawal threshold; siRNA; small interfering ribonucleic acid; TTBS; Tween/Tris-buffered saline solution; postoperati
The mTOR cell signaling pathway is crucial to the long-term protective effects of ischemic postconditioning against stroke
Keywords: CCA; common carotid artery; dMCAo; distal middle cerebral artery occlusion; GAP-43; growth associated protein 43; IPostC; Ischemic postconditioning; mTOR; mammalian target of rapamycin; MCA; middle cerebral artery; PFA; paraformaldehyde; PSD-95; postsynap
Perinatal fluoxetine prevents the effect of pre-gestational maternal stress on 5-HT in the PFC, but maternal stress has enduring effects on mPFC synaptic structure in offspring
Keywords: Synaptophysin; PSD-95; Glucocorticoid receptor; Sex differences; Neuroplasticity; HPA axis;
Disrupting interaction of PSD-95 with nNOS attenuates hemorrhage-induced thalamic pain
Keywords: PSD-95; nNOS; Protein-protein interaction; Thalamic pain; Hemorrhage;
Inhibitors of the NMDA-Nitric Oxide Signaling Pathway Protect Against Neuronal Atrophy and Synapse Loss Provoked by l-alpha Aminoadipic Acid-treated Astrocytes
Keywords: 2-DG; 2-deoxy-d-glucose; ANOVA; analyses of variance; ATP; Adenosine tri-phosphate; cDMEM; complete Dulbecco's Modified Eagle Medium; cDNA; complementary deoxyribonucleic acid; CM; conditioned media; cNBM; complete neurobasal A medium; CNS; central nerv
EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function
Keywords: βGal; β-Galactosidase; Aβ; amyloid-β; Abl; Abelson murine leukemia viral oncogene homolog; AD; Alzheimer's disease; AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; BLA; basolateral amygdala; CaMKI
l-Cysteine suppresses hypoxia-ischemia injury in neonatal mice by reducing glial activation, promoting autophagic flux and mediating synaptic modification via H2S formation
Keywords: AOAA; aminooxyacetic acid; CBS; cystathionine β synthase; CD86; cluster of differentiation 86; CNS; central nervous system; DAPI; 4,6-diamidino-2-phenylindole; DAO; d-amino acid oxidase; GFAP; glial fibrillary acidic protein; HBSS; Hanks Balanced Salt So
Cell adhesion and matricellular support by astrocytes of the tripartite synapse
Keywords: β (Greek Small Letter Beta): 03B2; α (Greek Small Letter Alpha): 03B1; δ (Greek Small Letter Delta): 03B4; γ (Greek Small Letter Gamma): 03B3; ACM; astrocyte-conditioned medium; AMIGO; adhesion molecule with IG-like domain; AMOG; A Molecule On Glia; A
Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats
Keywords: Traumatic brain injury; PSD-95; Neuroprotection; Excitotoxicity; Fimbria-fornix transection; Spatial delayed alternation;
ZL006 protects spinal cord neurons against ischemia-induced oxidative stress through AMPK-PGC-1α-Sirt3 pathway
Keywords: Spinal cord ischemia; PSD-95; nNOS; Sirt3; Mitochondrial dysfunction;
Radix Puerariae modulates glutamatergic synaptic architecture and potentiates functional synaptic plasticity in primary hippocampal neurons
Keywords: AP-5; (2R)-amino-5-phosphonovaleric acid; ARP2; actin-related protein 2; BDNF; brain-derived neurotrophic factor; DiO; 3,3-dioctadecyloxacarbocyanine perchlorate; DIV; day in vitro; DMSO; dimethyl sulfoxide; D-PBS; Dulbecco's phosphate buffered saline; FM
Human LRRK2 G2019S mutation represses post-synaptic protein PSD95 and causes cognitive impairment in transgenic mice
Keywords: ChaRP; challenge-adjusted rod performance; ITI; inter-trial interval; LRRK2; leucine-rich repeat kinase 2; NAD; novel arm discrimination; ORP; overall rod performance; PD; Parkinson's disease; PSD-95; post synaptic density protein; RAWM; radial arm wate
Bedside to bench to bedside research: Estrogen receptor beta ligand as a candidate neuroprotective treatment for multiple sclerosis
Keywords: MS; multiple sclerosis; EAE; experimental autoimmune encephalomyelitis; ER; estrogen receptor; MBP; myelin basic protein; NF200; neurofilament 200; PSD-95; post synaptic density-95; WM; white matter; GM; gray matter; CNS; central nervous system; Multiple
Alterations of ubiquitin related proteins in the pathology and development of schizophrenia: Evidence from human and animal studies
Keywords: Schizophrenia; Neurodevelopmental animal model; Human brain cohort; E2 ubiquitin conjugating enzyme; E3 ligases; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; DLPFC; dorsolateral prefrontal cortex; FBXL21; F-Box and Leucine rich repeat protein
Regular articleRunning-induced memory enhancement correlates with the preservation of thin spines in the hippocampal area CA1 of old C57BL/6 mice
Keywords: Spines; PSD-95; Memory; Aging; Physical training; Hippocampus;
Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice
Keywords: Sleep; Chronic sleep restriction; Alzheimer's disease; Amyloid-β oligomers; Cytokines; TNF-α; IL-1β; IL-6; Hippocampus; Synaptic proteins; Synaptophysin; PSD-95; Inflammation;
Archival ReportPsychosis Risk Candidate ZNF804A Localizes to Synapses and Regulates Neurite Formation and Dendritic Spine Structure
Keywords: Autism spectrum disorder; Bipolar disorder; Dendritic spine; GluN1; Human neurons; Induced pluripotent stem cells (iPSCs); Neural progenitor cells; PSD-95; Psychosis; Schizophrenia; Super-resolution microscopy; Synapse;
Synaptopathic mechanisms of neurodegeneration and dementia: Insights from Huntington's disease
Keywords: 5-HT; 5-hydroxytryptamine; 7,8-DHF; 7,8-dihydroxyflavone; ACh; acetylcholine; AD; adenosine; ADL; activities of daily living; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPK; 5â²AMP-activated protein kinase; BDNF; brain-derived neurotro
PDZ1 inhibitor peptide protects neurons against ischemia via inhibiting GluK2-PSD-95-module-mediated Fas signaling pathway
Keywords: PSD-95, Postsynaptic density protein 95; MLK3, Mixed Lineage Kinase 3; JNK, c-Jun N-terminal kinase; FADD, Fas associated death domain protein; DISC, death-inducing signaling complexCerebral ischemia; GluK2; PSD-95; Fas; FasL; Peptide
Research reportProtection of neuronal cells from excitotoxicity by disrupting nNOS-PSD95 interaction with a small molecule SCR-4026
Keywords: PSD-95; postsynaptic density protein-95; nNOS; neuronal nitric oxide synthase; NMDA; N-methyl-D-aspartate; OGD; Oxygen and glucose deprivation; MCAO; middle cerebral artery occlusion; BBB; blood-brain barrier; TTC; 2,3,5-Triphenyltetrazolium chloride; NSC
Metabotropic Glutamate Receptor and Fragile X Signaling in a Female Model of Escalated Aggression
Keywords: Aggression; Fragile X; mGluR5; Nucleus accumbens; Plasticity; PSD-95;
Differential regulation of synaptic and extrasynaptic α4 GABA(A) receptor populations by protein kinase A and protein kinase C in cultured cortical neurons
Keywords: PKA; PKC; α4 subunit; Serine phosphorylation; Expression; GABAAâ receptor; PKA; protein kinase A; PKC; protein kinase C; Sp-cAMPS; Sp-Adenosine 3â²,5â²-cyclic monophosphorothioate triethylammonium salt; Rp-cAMPS; Rp-Adenosine 3â²,5â²-cyclic monopho
The ADHD-linked human dopamine D4 receptor variant D4.7 induces over-suppression of NMDA receptor function in prefrontal cortex
Keywords: Human dopamine D4 receptor; Polymorphism; Attention deficit hyperactivity disorder; PSD-95; NMDA receptor; Novelty seeking behaviors