Dendritic Spine Instability in a Mouse Model of CDKL5 Disorder Is Rescued by Insulin-like Growth Factor 1
Keywords: CDKL5; dendritic spines; IGF-1; imaging; PSD-95; Rett syndrome;
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Cognitive impairments following cranial irradiation can be mitigated by treatment with a tropomyosin receptor kinase B agonist
Keywords: DHF; 7,8-dihydroxyflavone; BDNF; brain-derived neurotrophic factor; TrkB; tropomycin receptor kinase B; ERK; extracellular signal-regulated kinase; AKT; protein kinase B; PSD-95; post-synaptic density 95; SGZ; subgranular zone; BrdU; bromodeoxyuridine; Dc
Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases
Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer⿿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy
The soluble extracellular fragment of neuroligin-1 targets Aβ oligomers to the postsynaptic region of excitatory synapses
Keywords: Neuroligin-1; Aβ oligomer; Excitatory synapses; Hippocampal neurons; Aβo; Amyloid-β oligomers; AD; Alzheimer's disease; APP/PS1; double-transgenic mice; LTP; long-term potentiation; PSD-95; postsynaptic density protein-95; NMDA receptors; N-methyl-d-as
Hippocampal neuronal maturation triggers post-synaptic clustering of brain temperature-sensor TRPV4
Keywords: TRPV4; Hippocampus; Development; Synapse; Cerebellum; PSD-95;
Entropic clocks in the service of electrical signaling: 'Ball and chain' mechanisms for ion channel inactivation and clustering
Keywords: 'Ball and chain'; Clustering; Entropic chain; Inactivation; Intrinsic disorder; Scaffold protein; PSD-95; Voltage-dependent potassium channel;
Lurasidone and fluoxetine reduce novelty-induced hypophagia and NMDA receptor subunit and PSD-95 expression in mouse brain
Keywords: Depression; Hippocampus; Prefrontal cortex; Glutamate; PSD-95;
Abnormal cortical lysosomal β-hexosaminidase and β-galactosidase activity at post-synaptic sites during Alzheimer's disease progression
Keywords: CT-B; cholera toxin B subunit; flot-2; flotillin-2; Gal; β-galactosidase; GM1; Galβ1,3GalNAcβ1,4-(NeuAcα2,3)-Galβ1,4Glc-ceramide; GM2; 3GalNAcβ1,4-(NeuAcα2,3)-Galβ1,4Glc-ceramide; GM3; NeuAcα2,3Galβ1,4Glc-ceramide; GSL; glycosphingolipid; Hex; Î
GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity
Keywords: CNS; central nervous system; HIV-1; human immunodeficiency virus-1; HAND; HIV-1-associated neurocognitive disorders; cART; combination antiretroviral therapy; Tat; trans-activator of transcription; gp120; glycoprotein 120; GSK3β; glycogen synthase kinase
HIV-1 differentially modulates autophagy in neurons and astrocytes
Keywords: HIV brain; HIV-1 neurotoxicity; PSD-95; HIV-infected macrophages; HIV astrocytes; Autophagosomes;
Regulation of hippocampal synaptic plasticity by BDNF
Keywords: 4E-BPs; eIF4E-binding proteins; 5-HT; 5-hydroxytryptamine; ADF; actin-depolymerising factor; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; AMPA receptors; Arc; activity-regulated cytoskeleton-associated protein; BDNF; brain-derived n
Wnt5a inhibits K+ currents in hippocampal synapses through nitric oxide production
Keywords: Wnt5a; wingless-type family member 5a; NMDA; N-methyl d-aspartic acid; NO; nitric oxide; 7-NI; 7-nitroindazole; ROR2; receptor tyrosine kinase-like orphan receptor 2; sFRP-2; soluble frizzled related protein 2; DVL; Disheveled; Wnt/PCP; Wnt/planar cell po
Small-molecule inhibitors at the PSD-95/nNOS interface attenuate MPP+-induced neuronal injury through Sirt3 mediated inhibition of mitochondrial dysfunction
Keywords: Parkinson's disease; PSD-95; nNOS; Mitochondrial dysfunction; Sirt3
Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration
Keywords: LRRK2; leucine rich repeat kinase 2; LRRK2-3HA; C-terminal 3Ã-hemagglutinin tagged LRRK2; cDNA; complementary deoxyribonucleic acid; mEPSC; miniature excitatory postsynaptic current; PD; Parkinson's disease; AMPA; (2-amino-3-(5-methyl-3-oxo-1,2-oxazol-4-
Investigation into the effects of prenatal alcohol exposure on postnatal spine development and expression of synaptophysin and PSD95 in rat hippocampus
Keywords: Fetal ethanol; Synaptophysin; PSD-95; Spine counts; Hippocampus; Rat
Tripchlorolide improves age-associated cognitive deficits by reversing hippocampal synaptic plasticity impairment and NMDA receptor dysfunction in SAMP8 mice
Keywords: AD; Alzheimer's Disease; BDNF; brain-derived neurotrophic factor; CaMKII; calcium/calmodulin-dependent protein kinase II; CREB; cyclic AMP-response element binding protein; EPSPs; excitatory postsynaptic potentials; LTP; long-term potentiation; MWM; Morri
Regular ArticleImpaired Src signaling and post-synaptic actin polymerization in Alzheimer's disease mice hippocampus - Linking NMDA receptors and the reelin pathway
Keywords: ApoER-2; apolipoprotein E receptor-2; Dab1; disabled-1; F-actin; filamentous-actin; G-actin; glomerular-actin; GKAP; guanylate kinase-associated protein; NMDAR; N-methyl-d-aspartate receptors; PSD-95; postsynaptic density-95; VLDLR; very-low-density-lipop
Role of the ubiquitin-proteasome system in brain ischemia: Friend or foe?
Keywords: 3-MA; 3-methyladenine; 15d-PHJ2; 15-deoxy-Î12,14-prostaglandin J2; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole proprionic acid; AMPAR; AMPA receptors; APC/C; anaphase-promoting complex/cyclosome; APV; D-aminophosphonovalerate; ATF4; activating transcri
Ligand binding of PDZ domains has various roles in the synaptic clustering of SAP102 and PSD-95
Keywords: AMPA; α-amino-3-hydroxy-5-methylisoxazole-4-propionate; DIV; day in vitro; EGFP; enhanced green fluorescent protein; MAGUK; membrane-associated guanylate kinase; PBS; phosphate-buffered saline; PDZ; PSD-95/discs large/zona occludens-1; PSD; postsynaptic
Research reportNeotrofin reverses the effects of chronic unpredictable mild stress on behavior via regulating BDNF, PSD-95 and synaptophysin expression in rat
Keywords: AD; Alzheimer's disease; ANOVA; analysis of variance; BDNF; brain derived neurotrophic factor; CUMS; chronic unpredictable mild stress; NGF; nerve growth factor; NT-3; neurotrophin-3; NT-4; neurotrophin-4; PSD-95; postsynaptic density protein 95; Neotrofi
Prenatal stress increased Snk Polo-like kinase 2, SCF β-TrCP ubiquitin ligase and ubiquitination of SPAR in the hippocampus of the offspring at adulthood
Keywords: Prenatal stress; PSD-95; Spine associated RapGAP (SPAR); Serum inducible kinase (Snk); β-Tranducin containing protein (β-TrCP); NMDA receptor; Ubiquitin proteasome system; Hippocampus;
Amyloid-β oligomer synaptotoxicity is mimicked by oligomers of the model protein HypF-N
Keywords: PSD-95; Memory; Neurodegeneration; Neurotransmission; Fibrils; Amyloidosis;
Extracellular chaperones prevent Aβ42-induced toxicity in rat brains
Keywords: α2M; α2-macroglobulin; AD; Alzheimer's disease; Aβ; amyloid-beta peptide; BSA; bovine serum albumin; CNS; Central Nervous System; Clu; clusterin; CM-H2DCFDA; 2â²,7â²-dichlorodihydrofluorescein diacetate; DMSO; dimethylsulfoxide; DTT; dithiothreitol;
Sex-specific effects of bisphenol-A on memory and synaptic structural modification in hippocampus of adult mice
Keywords: Bisphenol A; Learning and memory; Synaptic structure; PSD-95;
Different effects of the NMDA receptor antagonists ketamine, MK-801, and memantine on postsynaptic density transcripts and their topography: Role of Homer signaling, and implications for novel antipsychotic and pro-cognitive targets in psychosis
Keywords: ACC; anterior cingulate cortex; ANOVA; one-way analysis of variance; Arc; activity-related cytoplasmic protein; BDNF; brain-derived neurotrophic factor; core; core of the nucleus accumbens; DEPC; diethylpyrocarbonate; dlCP; dorsolateral caudate putamen; d
The type II cGMP dependent protein kinase regulates GluA1 levels at the plasma membrane of developing cerebellar granule cells
Keywords: AMPA; α-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate; AMPAR; AMPA receptor; Angeli's salt; disodium diazem-1-ium-1,2,2-triolate; CaCMKII; Ca2 +-calmodulin kinase II; cGK; cGMP-dependent protein kinase; cGKI; cGMP-dependent protein kinase type I; cGK
Effects of different amyloid β-protein analogues on synaptic function
Keywords: Amyloid-β protein; Long-term potentiation; Synaptic transmission; Dentritic spines; Methionine 35; Synaptophysin; PSD-95; mEPCS; Alzheimer's disease;
Advances in thin tissue Golgi-Cox impregnation: Fast, reliable methods for multi-assay analyses in rodent and non-human primate brain
Keywords: 3-D; 3-dimensional; 6-OHDA; 6-hydroxydopamine; ABC; avidin biotin peroxidase complex; BrdU; bromodeoxyuridine; DA; dopamine; D1R; dopamine D1 receptor; D2R; dopamine D2 receptor; DAB; 3,3â²-diaminobenzidine tetrahydrochloride; DMSO; dimethyl sulfoxide; E
Involvement of the proteasome and caspase activation in hippocampal long-term depression induced by the serine protease subtilisin
Keywords: aCSF; artificial cerebrospinal fluid; CED; Cambridge Electronic Design; DHPG; dihydroxyphenylglycine; fEPSPs; field excitatory synaptic potentials; HRP; horseradish peroxidase; LTD; long-term depression; LTP; long-term potentiation; MG132; N-[(phenylmetho
Selective reduction of drebrin and actin in dendritic spines of hippocampal neurons by activation of 5-HT2A receptors
Keywords: Dendritic spine; Actin; 5-HT2A receptor; Hippocampal neurons; Drebrin; PSD-95;
Social isolation produces anxiety-like behaviors and changes PSD-95 levels in the forebrain
Keywords: Isolation rearing; Anxiety; Novelty-induced hypophagia; PSD-95; Synapse;
Glutamate receptor dysfunction and drug targets across models of autism spectrum disorders
Keywords: mGluR; Kainate; NMDA; SHANK; Neuroligin; PSD-95; MPEP
Involvement of neuronal nitric oxide synthase in cognitive impairment in isoflurane-treated rats
Keywords: POCD; postoperative cognitive dysfunction; nNOS; neuronal nitric oxide synthase; NO; nitric oxide; PSD-95; postsynaptic density protein 95; NMDA; N-methyl-d-aspartate; PBS; phosphate buffered saline; BSA; bovine serum albumin; ABC; avidin-biotin-perox
Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95
Keywords: CAR; Coxsackievirus and adenovirus receptor; ASIC3; acid sensing ion channel 3; PSD-95; post-synaptic density 95; PDZ; PSD-95/Drosophila discs-large protein/zonula occludens protein; Ab; antibody; IP; immunoprecipitation; Coxsackievirus and adenovirus rec
NMDA receptor/amyloid precursor protein interactions: A comparison between wild-type and amyloid precursor protein mutations associated with familial Alzheimer's disease
Keywords: Aβ; amyloid-β peptides; apoEr2; apolipoprotein E receptor 2; APP; amyloid precursor protein; ELISA; enzyme linked immunoadsorbent assay; NMDA; N-methyl-d-aspartate; NR1; NR2A, etc.NMDA receptor NR1 subunit, NR2A subunit, etc.; PBS; phosphate buffered; P
Synaptic localization of acylpeptide hydrolase in adult rat telencephalon
Keywords: Acylpeptide hydrolase; Excitatory synapse; Synaptic localization; Rat hippocampus; ACPH; acylpeptide hydrolase; Aβ; amyloid beta peptide; AChE; acetylcholinesterase; AANA; acetyl-alanyl-p-nitroanilide; DTNB; dithiobisnitrobenzoate; DDVP; 2,2-dichloroviny
CaMKII antisense oligodeoxynucleotides protect against ischemia-induced neuronal death in the rat hippocampus
Keywords: CaMKII antisense oligodeoxynucleotides; Neuroprotection; CaMKII; GluR6; PSD-95; Cerebral ischemia;
Research ReportInteractions and phosphorylation of postsynaptic density 93 (PSD-93) by extracellular signal-regulated kinase (ERK)
Keywords: PDZ; PSD-95; MAPK; JNK; Synapse; Signaling; Striatum;
Chronic ethanol up-regulates the synaptic expression of the nuclear translational regulatory protein AIDA-1 in primary hippocampal neurons
Keywords: AIDA-1; Chronic ethanol; Synapse-to-nucleus signaling; NMDA receptors; Cajal bodies; PSD-95
Research ReportEffects of skilled and unskilled training on functional recovery and brain plasticity after focal ischemia in adult rats
Keywords: Focal ischemia; Stroke rehabilitation; Neuroplasticity; Synapsin-I; PSD-95; GFAP;
Vamping: Stereology-based automated quantification of fluorescent puncta size and density
Keywords: Confocal microscopy; Electron microscopy; Image analysis; Stereology; PSD-95; Postsynaptic densities
Testosterone has sublayer-specific effects on dendritic spine maturation mediated by BDNF and PSD-95 in pyramidal neurons in the hippocampus CA1 area
Keywords: Spine morphology; Maturation; CA1; Testosterone; BDNF; PSD-95;
AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly
Keywords: Synaptosome; Flow cytometry; Parkinson's disease; Synaptophysin; PSD-95; A11 antibody; OC antibody;
Research reportAmitriptyline attenuates astrocyte activation and morphine tolerance in rats: Role of the PSD-95/NR1/nNOS/PKCγ signaling pathway
Keywords: Amitriptyline; Astrocyte activation; Morphine tolerance; PSD-95; NMDA receptors; NR1 subunit; nNOS; PKCγ;
P38 MAPK is involved in enhanced NMDA receptor-dependent excitotoxicity in YAC transgenic mouse model of Huntington disease
Keywords: aCSF; artificial cerebrospinal fluid; co-IP; co-immunoprecipitation; DIV; days in vitro; ERK; extracellular signal-regulated protein kinase; Ex-NMDARs; extrasynaptic NMDARs; GFP; green fluorescent protein; HD; Huntington disease; HIV-1; human immunodefici
Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL
Keywords: Aging; Hippocampus; CA3; Astrocytes; Microglia; CD200; Synaptophysin; PSD-95; Morphometric analysis; Immunoelectron microscopy;
Immunolocalization of NR1, NR2A, and PSD-95 in rat hippocampal subregions during postnatal development
Keywords: NR1; NR2A; PSD-95; Hippocampus; Development; Rat
Spinal SIRPα1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats
Keywords: Spinal nerve ligation; SIRPα1; SHP2; PSD-95; NMDA; NR2B; NSC-87877;
The PSD-95/nNOS complex: New drugs for depression?
Keywords: NMDA receptors; PSD-95; nNOS; Protein–protein interactions; PDZ domains; Depression
Ovarian steroids increase spinogenetic proteins in the macaque dorsal raphe
Keywords: estradiol; immunocytochemistry; PSD-95; progesterone; RhoGTPase; serotonin; ANOVA; analysis of variance; Cdc42; cell division control protein 42 homolog; DAB; diaminobenzidine; DPX; dibutyl phthalate and xylene; E; estradiol; E+P; estradiol+progesterone;