Coxsackievirus and adenovirus receptor (CAR) mediates trafficking of acid sensing ion channel 3 (ASIC3) via PSD-95

► CAR indirectly interacts with ASIC3 via a PDZ-based interaction with PSD-95. ► CAR mediates junctional localization of ASIC3 and PSD-95. ► CAR rescues PSD-95-mediated inhibition of ASIC3 currents.