کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
6020179 1580389 2015 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
HIV-1 differentially modulates autophagy in neurons and astrocytes
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
HIV-1 differentially modulates autophagy in neurons and astrocytes
چکیده انگلیسی


- HIV-1 differentially modulates neuro-glial toxicity.
- HIV-1 induces neuro-glial damage by suppressing autophagy.
- Suppression of autophagy in neuro-glial cells by HIV-1 is without viral infection.
- Autophagy induction in neuro-glial cells protects against HIV-1 insult.

Autophagy, a lysosomal degradative pathway that maintains cellular homeostasis, has emerged as an innate immune defense against pathogens. The role of autophagy in the deregulated HIV-infected central nervous system (CNS) is unclear. We have found that HIV-1-induced neuro-glial (neurons and astrocytes) damage involves modulation of the autophagy pathway. Neuro-glial stress induced by HIV-1 led to biochemical and morphological dysfunctions. X4 HIV-1 produced neuro-glial toxicity coupled with suppression of autophagy, while R5 HIV-1-induced toxicity was restricted to neurons. Rapamycin, a specific mTOR inhibitor (autophagy inducer) relieved the blockage of the autophagy pathway caused by HIV-1 and resulted in neuro-glial protection. Further understanding of the regulation of autophagy by cytokines and chemokines or other signaling events may lead to recognition of therapeutic targets for neurodegenerative diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroimmunology - Volume 285, 15 August 2015, Pages 106-118
نویسندگان
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