کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8839932 | 1613766 | 2018 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stress-induced hippocampus Npas4 mRNA expression relates to specific psychophysiological patterns of stress response
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
EGR1TrkBc-fosPSD-95N-methyl-d-aspartateNMDAPPIAHsp-70FBJ osteosarcoma oncogeneHprtCRFNpas4t-PAEPMADORA1ribosomal protein large P0NF-κB1IκBαCTLPeptidylprolyl isomerase A (cyclophilin A)Bcl2BDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز post-traumatic stress disorder - اختلال استرس پس از ضربهPTSD - اختلال استرسی پس از ضایعه روانیArbp - اربپStress - استرس یا فشار روانیgamma amino butyric acid - اسید گاما آمینو بوتیریکAnxiety - اضطرابelevated plus maze - بالا به همراه پیچ و خمanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancetropomyosin receptor kinase B - تریپومیوسین گیرنده کیناز BLocomotion - حرکتSham - شامcorticotropin releasing factor - عامل آزاد کننده کورتیکوتروپینBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزnuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor alpha - فاکتور هسته ای تقویت کننده ژن پلیپپتیدی نور کاپا در سلول های بتا-مهارگر آلفاArc - قوسB-cell lymphoma 2 - لنفوم سلول B 2HPA - میلی بار یا هکتوپاسکالHippocampus - هیپوکامپ Hypoxanthine phosphoribosyltransferase 1 - هیپوکسانتین فسفریبوسیل ترانسفراز 1early growth response 1 - پاسخ رشد اولیه 1heat shock protein 70 - پروتئین شوک حرارت 70postsynaptic density protein 95 - پروتئین چگالی Postynaptic 95AID - کمکControl - کنترلfootshock - کوتولهGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله

چکیده انگلیسی
Neuronal Per-Arnt-Sim (PAS) domain protein 4 (Npas4) is a key protein that intervenes in GABA synapse scaling and neurotrophicity enhancing. Since GABA and neurotrophicity are implicated in stress response and Npas4-deficient rodents exhibit behavioral alterations, an investigation was designed in rats to verify whether stress-induced spontaneous hippocampus Npas4 mRNA expression would be associated with specific patterns of stress response. The rats were exposed to one of three stressor levels: no stress (CTL, nâ¯=â¯15), exposure to a footshock apparatus (Sham, S, nâ¯=â¯40) and footshock (F, nâ¯=â¯80). After stress exposure the S and F rats were tested in an activity cage, and subsequently in an elevated plus maze (EPM), just prior to the sacrifice. Using cluster analysis, the animals already assigned to a stress level were also distributed into 2 subgroups depending on their Npas4 mRNA levels. The low (L) and high (H) Npas4 expression subgroups were identified in the S and F groups, the CTL group being independent of the Npas4 levels. The Npas4 effect was studied through the interaction between stress (S and F) and Npas4 level (L and H). The biological stress response was similar in H and L rats, except blood corticosterone that was slightly lower in the H rats. The H rats were more active in the actimetry cage and presented higher levels of exploration in the EPM. They also exhibited higher hippocampus activation, as assessed by the c-fos, Egr1 and Arc mRNA levels. Therefore high Npas4 expression favors stress management.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1679, 15 January 2018, Pages 75-83
Journal: Brain Research - Volume 1679, 15 January 2018, Pages 75-83
نویسندگان
Jean-Baptiste Drouet, André Peinnequin, Patrice Faure, Josiane Denis, Nadine Fidier, Renaud Maury, Alain Buguet, Raymond Cespuglio, Frédéric Canini,