کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415776 | 1292941 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus
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کلمات کلیدی
5-HTaCSF5-HIAA5-hydroxytryptamine, serotonin - 5-hydroxytryptamine، serotonin5-Hydroxyindoleacetic acid - 5-هیدروکسی سدیم اسیدCNS - دستگاه عصبی مرکزیcentral nervous system - سیستم عصبی مرکزیCerebrospinal fluid - مایع مغزی نخاعیCSF - مایع مغزی نخاعیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیCORT - کورتCorticosterone - کورتیکوسترون
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus Local inhibition of organic cation transporters increases extracellular serotonin in the medial hypothalamus](/preview/png/9415776.png)
چکیده انگلیسی
In the rat dorsomedial hypothalamus (DMH), serotonin (5-HT) concentrations are altered rapidly in response to acute stressors. The mechanism for rapid changes in 5-HT concentrations in the DMH is not clear. We hypothesize that the mechanism involves corticosteroid-induced alterations in the uptake of 5-HT from extracellular fluid through the action of corticosterone-sensitive organic cation transporters (OCTs). To determine if OCTs affect the clearance of 5-HT from the extracellular fluid compartment within the medial hypothalamus (MH), the OCT blocker, decynium 22 (0, 10, 30, or 100 μM), was perfused into the MH via a microdialysis probe, and dialysate 5-HT concentrations were measured at 20 min intervals. In addition, home cage behavior was measured both before and after drug administration. Inhibition of OCTs in the MH resulted in a reversible dose-dependent increase in extracellular 5-HT concentration. Increases in extracellular 5-HT concentrations were associated with increases in grooming behavior in rats treated with the highest concentration of decynium 22. No other behavioral responses were observed following administration of any concentration of decynium 22. These findings are consistent with the hypothesis that OCTs in the MH play an important role in the regulation of serotonergic neurotransmission and specific behavioral responses. Because the MH plays an important role in the neuroendocrine, autonomic, and behavioral responses to stress-related stimuli, these data lead to new questions regarding the role of interactions between corticosterone and corticosterone-sensitive OCTs in stress-induced 5-HT accumulation within the MH as well as the physiological and behavioral consequences of these interactions.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1063, Issue 1, 23 November 2005, Pages 69-76
Journal: Brain Research - Volume 1063, Issue 1, 23 November 2005, Pages 69-76
نویسندگان
Na Feng, Bing Mo, Philip L. Johnson, Miles Orchinik, Christopher A. Lowry, Kenneth J. Renner,