کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415870 | 1292947 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Urotensin II acts as a modulator of mesopontine cholinergic neurons
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کلمات کلیدی
UIIUrotensin II receptorPPTgLDTgVTAintracerebroventricularICVPPINACChronoamperometryPedunculopontine tegmentum - Pedunculopontine TEGMENTUMElectrophysiology - الکتروفیزیولوژیNeurotransmitters, Modulators, Transporters, and Receptors - انتقال دهنده های عصبی، مدولاتورها، حمل کننده ها و گیرنده هاlaterodorsal tegmentum - تیرانداز بعدیLocomotion - حرکتPrepulse inhibition - مهار پیش قاعدگیventral tegmental area - ناحیه تگمنتوم شکمیNucleus accumbens - هسته accumbensPeptides: anatomy and physiology - پپتیدها: آناتومی و فیزیولوژیUrotensin II - یوتنسین II
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Urotensin II acts as a modulator of mesopontine cholinergic neurons Urotensin II acts as a modulator of mesopontine cholinergic neurons](/preview/png/9415870.png)
چکیده انگلیسی
Urotensin II (UII) is a vasomodulatory peptide that was not predicted to elicit CNS activity. However, because we have recently shown that the urotensin II receptor (UII-R) is selectively expressed in rat mesopontine cholinergic (MPCh) neurons, we hypothesize that UII may have a central function. The present study demonstrates that the UII system is able to modulate MPCh neuron activity. Brain slice experiments demonstrate that UII excites MPCh neurons of the mouse laterodorsal tegmentum (LDTg) by activating a slow inward current. Furthermore, microinfusion of UII into the ventral tegmental area produces a sustained increase in dopamine efflux in the nucleus accumbens, as measured by in vivo chronoamperometry. In agreement with UII activation of MPCh neurons, intracerebroventricular injections of UII significantly modulate ambulatory movements in both rats and mice but do not significantly affect startle habituation or prepulse inhibition. The present study establishes that UII is a neuromodulator that may be exploited to target disorders involving MPCh dysfunction.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1059, Issue 2, 19 October 2005, Pages 139-148
Journal: Brain Research - Volume 1059, Issue 2, 19 October 2005, Pages 139-148
نویسندگان
Stewart D. Clark, Hans-Peter Nothacker, Charles D. Blaha, Christopher J. Tyler, Dee M. Duangdao, Stephen L. Grupke, David R. Helton, Christopher S. Leonard, Olivier Civelli,