کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9415894 1292948 2005 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures, and early postnatal death in mice
چکیده انگلیسی
Taken together with the known neurochemistry and neuronal distribution of the Asc-1 transporter, these results indicate that the mechanism underlying the behavioral hyperexcitability in mutant mice is likely due to overactivation of NMDA receptors, presumably resulting from elevated extracellular d-serine. Our study provides the first evidence to support the notion that Asc-1 transporter plays a critical role in regulating neuronal excitability, and indicate that the transporter is vital for normal CNS function and essential to postnatal survival of mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1052, Issue 2, 9 August 2005, Pages 212-221
نویسندگان
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