کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9415992 | 1614328 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of circulating androgen levels in effects of apoE4 on cognitive function
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
Androgen - آندروژنapolipoprotein E - آپولیپوپروتئین EPassive avoidance - اجتناب ناپذیرCastration - اختهکردن، اختهسازی، کشیدنِ بیضهObject recognition - تشخیص شیNeural Basis of Behavior - مبانی عصبی رفتاریSpatial learning and memory - یادگیری فضایی و حافظهLearning and memory: physiology - یادگیری و حافظه: فیزیولوژی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Compared with apoE2 and E3, apoE4 increases the risk of cognitive impairments and of developing Alzheimer's disease (AD). ApoE4 interacts with female sex, further increasing AD risk. Previously, we showed that female Apoeâ/â mice are more susceptible to apoE4-induced cognitive deficits than male mice. Androgens protect against these deficits and apoE4 male mice are more sensitive to acute blockade of androgen receptors than apoE3 male mice. To determine the chronic effects of reduced circulating androgen levels on susceptibility to the effects of apoE4 on cognitive function in males, we castrated and sham-castrated apoE4, apoE3, and Apoeâ/â male mice and behaviorally compared them 3 months later. Castration impaired novel location recognition in apoE4, but not apoE3 or Apoeâ/â, mice. In contrast, castration impaired novel object recognition and spatial memory retention in the water maze in Apoeâ/â, but not apoE3 or apoE4, mice. On the contrary, castrated, but not sham-castrated, apoE4 mice showed improved acquisition over the first two hidden platform sessions and spatial memory retention in the first probe trial. While apoE3 and Apoeâ/â mice increased their exploratory times with the objects in the trial with the novel object, apoE4 mice did not. ApoE4 mice required more trials than apoE3 or Apoeâ/â mice to reach criterion during passive avoidance training, but castration did not modulate passive avoidance learning or memory. Thus, androgens have differential roles in object recognition and spatial learning and memory in the water maze, depending on whether or not apoE4 is present.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1053, Issues 1â2, 16 August 2005, Pages 88-96
Journal: Brain Research - Volume 1053, Issues 1â2, 16 August 2005, Pages 88-96
نویسندگان
Timothy Pfankuch, Angela Rizk, Reid Olsen, Cara Poage, Jacob Raber,