کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416126 | 1614330 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Long-lasting rewarding effects of morphine induced by drug primings
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Long-lasting rewarding effects of morphine induced by drug primings Long-lasting rewarding effects of morphine induced by drug primings](/preview/png/9416126.png)
چکیده انگلیسی
To evaluate the persistence of the rewarding effects of morphine, the acquisition, maintenance, extinction and reinstatement of a conditioned place preference (CPP) was assessed in OF1 mice. In Experiment 1, the persistence of morphine-induced CPP was evaluated weekly. Mice showed CPP after four sessions of conditioning with 5, 10, 20 and 40 mg/kg of morphine, which lasted 0, 1, 2 and 4 weeks, respectively. In Experiment 2, after four sessions of conditioning with 40 mg/kg of morphine, the effects of four schedules of extinction differing in the time interval (2, 4, 6 or 8 weeks) between sessions were evaluated. CPP was no longer evident after 8 weeks for the groups examined each 2 or 8 weeks and after 12 weeks for the groups examined each 4 and 6 weeks. After extinction, the reinstating effects of a priming dose of 20 mg/kg of morphine were demonstrated. This procedure of extinction/reinstatement was repeated with a decreasing priming dose of morphine (10, 5, 2.5 and 1.25 mg/kg) until a noneffective dose was found. These results show that morphine-induced CPP is very persistent over time, suggesting that drug exposure induces long-lasting changes in the brain, which supports the idea that drug addiction must be considered as a chronic, lifelong disorder.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1050, Issues 1â2, 19 July 2005, Pages 53-63
Journal: Brain Research - Volume 1050, Issues 1â2, 19 July 2005, Pages 53-63
نویسندگان
B. Ribeiro Do Couto, M.A. Aguilar, M. RodrÃguez-Arias, J. Miñarro,