کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9416139 1614330 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Synaptic localization of receptor-type protein tyrosine phosphatase ζ/β in the cerebral and hippocampal neurons of adult rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Synaptic localization of receptor-type protein tyrosine phosphatase ζ/β in the cerebral and hippocampal neurons of adult rats
چکیده انگلیسی
Receptor-type protein tyrosine phosphatase (RPTP) ζ/β is a nervous tissue-specific chondroitin sulfate proteoglycan. In this study, we investigated the immunohistochemical localization of RPTPζ/β in adult rat cerebral cortex and hippocampus at light and electron microscopic levels. Double labeling immunofluorescence microscopy revealed that the immunoreactivity of RPTPζ/β was observed at MAP2-positive dendrites and PSD-95-positive spines of pyramidal neurons in the cerebral cortex and hippocampus. Electron microscopic observation demonstrated a strong immunoreactivity of RPTPζ/β at the postsynaptic membrane of dendritic spines and shafts, and its moderate immunoreactivity at the dendritic membrane. In cultured cortical neurons, the immunoreactivity of RPTPζ/β was observed at some of PSD-95-positive spines. These results demonstrate that RPTPζ/β is localized mainly at the postsynaptic membrane of pyramidal neurons in adult cerebral cortex and hippocampus.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1050, Issues 1–2, 19 July 2005, Pages 163-169
نویسندگان
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