کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416299 | 1614333 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Stress hormone secretion is altered by central administration of intermedin/adrenomedullin-2
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کلمات کلیدی
Intermedinadrenomedullin - آدرنومدولینadrenocorticotropin - آدرنوکورتیکوتروپینoxytocin - اکسیتوسینEndocrine and autonomic regulation - تنظیم غدد درون ریز و اتونومیکcorticotropin-releasing factor - عامل تخریب کورتیکوتروپینHypothalamic–pituitary–adrenal regulation - مقررات هیپوتالاموس-هیپوفیو-آدرنالHypothalamus - هیپوتالاموسvasopressin - وازوپرسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Intermedin/Adrenomedullin-2 (IMD), a newly described peptide with structural homology to adrenomedullin (AM), is present in brain and pituitary gland and binds to the same receptors as AM and calcitonin gene-related peptide (CGRP). We hypothesized that IMD would exert actions similar to AM and CGRP and previously have demonstrated that indeed IMD, like AM and CGRP, increases sympathetic tone and inhibits feeding and drinking when administered centrally. Here, we extend those observations by demonstrating that like AM, IMD acts in brain to stimulate the secretions of prolactin (PRL) and adrenocorticotropin (ACTH) and to inhibit the secretion of growth hormone (GH) in conscious rats. In addition, in conscious rats, central administration of IMD results in increased plasma levels of oxytocin (OT) and vasopressin (AVP). The ability of IMD to activate the hypothalamo-pituitary-adrenal (HPA) axis can be blocked by intravenous pretreatment with the corticotropin releasing factor (CRF) antagonist, astressin. These results suggest that multiple members of the AM family of peptides may be involved in the cardiovascular, behavioral and neuroendocrine responses to stress.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1045, Issues 1â2, 31 May 2005, Pages 199-205
Journal: Brain Research - Volume 1045, Issues 1â2, 31 May 2005, Pages 199-205
نویسندگان
Meghan M. Taylor, Willis K. Samson,