Chronic ether stress-induced response of urocortin 1 neurons in the Edinger-Westphal nucleus in the mouse

This paper is the first to demonstrate that Ucn1 mRNA-expressing neurons in the E-WN show a non-habituating Fos response to a chronic homotypic ether challenge that also resulted in a reliable down-regulation of E-WN Ucn1 mRNA levels vs. acutely stressed animals. Based on these results, we propose that the E-WN-Ucn1 system represents a novel stress adaptation pathway, which may play an important role in coping with chronic challenges.