کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9416382 1292967 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Ketogenic diet prevents clusterin accumulation induced by kainic acid in the hippocampus of male ICR mice
چکیده انگلیسی
We investigated the effect of ketogenic diet (KD) on clusterin accumulation in the kainic acid (KA)-induced seizure model. Two days after KA administration, strong clusterin-like immunoreactivity (IR) was detected in the hippocampus in the normal diet (ND)-fed mice. But in the KD-fed mice, few clusterin-like IR was detected. These results indicate that KD has neuroprotective effects throughout diminishing nuclear clusterin accumulation that is involved in caspase-3 independent cell death mechanism.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1042, Issue 1, 25 April 2005, Pages 114-118
نویسندگان
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