کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416435 | 1614334 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Neuronal nitric oxide synthase and gonadal steroid interaction in the MPOA of male rats: Co-localization and testosterone-induced restoration of copulation and nNOS-immunoreactivity
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کلمات کلیدی
Medial preoptic area (MPOA)Male sexual behavior - رفتار جنسی مذکرNeural bases of behavior - مبانی عصبی رفتاریNitric oxide synthase (NOS) - نیتریک اکساید سنتاز (NOS)Hormonal control of reproductive behavior - کنترل هورمونی رفتار باروریAndrogen Receptor - گیرنده آندروژنیEstrogen receptor - گیرنده استروژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Neuronal nitric oxide synthase and gonadal steroid interaction in the MPOA of male rats: Co-localization and testosterone-induced restoration of copulation and nNOS-immunoreactivity Neuronal nitric oxide synthase and gonadal steroid interaction in the MPOA of male rats: Co-localization and testosterone-induced restoration of copulation and nNOS-immunoreactivity](/preview/png/9416435.png)
چکیده انگلیسی
Neuronal nitric oxide synthase (nNOS) in the medial preoptic area (MPOA) has been implicated in various physiological functions, including male rat copulation. Based on their apparent sensitivity to gonadal steroid manipulation, we hypothesized that nNOS cells contain steroid receptors, and the testosterone-induced restoration of nNOS-immunoreactivity in castrates should accompany the restoration of copulation. In Experiment 1, we investigated co-localization of nNOS with the androgen receptor (AR) and the estrogen receptor alpha (ERα) using immunocytochemistry. We found regionally specific co-localizations of nNOS-AR and nNOS-ERα. In Experiment 2, we investigated the relationship between MPOA nNOS-immunoreactivity (ir) and copulatory measures in the testosterone-induced restoration paradigm in castrates. The restoration of various copulatory measures was accompanied by an increase in optical density of nNOS-ir, but not in the number of nNOS-ir cells. These data provide additional evidence supporting the role of MPOA nitric oxide in male rat copulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1043, Issues 1â2, 10 May 2005, Pages 205-213
Journal: Brain Research - Volume 1043, Issues 1â2, 10 May 2005, Pages 205-213
نویسندگان
Satoru Sato, Claudean S. Braham, Susan K. Putnam, Elaine M. Hull,