α-Synuclein-positive structures induced in leupeptin-infused rats

This is the first report of experimentally induced in vivo accumulation of α-synuclein in non-transgenic rodent brain injected with a well-characterized protease inhibitor by an infusion pump. The present finding suggests that the local accumulation of α-synuclein might be induced by the impaired metabolism of α-synuclein, which are likely related to lysosomal or ubiquitin-independent proteasomal systems.