کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416463 | 1614335 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiovascular effects of angiotensin II and angiotensin-(1-7) at the RVLM of trained normotensive rats
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کلمات کلیدی
rostral ventrolateral medulla - آرام آرامPhysical training - آموزش فیزیکیAngiotensin II - آنژیوتانسین دوAngiotensin-(1–7) - آنژیوتانسین- (1-7)Endocrine and autonomic regulation - تنظیم غدد درون ریز و اتونومیکCardiovascular regulation - تنظیم قلب و عروقrenin-angiotensin system - سیستم رنین-آنژیوتانسین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We evaluated the effect of physical training on the cardiovascular responses produced by angiotensin peptides at the rostroventrolateral medulla (RVLM) of non-anesthetized normotensive rats. The RVLM pressor effect induced by Ang II was significantly greater in trained rats, while, in contrast, the Ang-(1-7) pressor effect was significantly smaller in trained in comparison to sedentary rats. In addition, the RVLM microinjection of Losartan (AT1 Ang II receptor antagonist) or A-779 (Ang-(1-7) receptor antagonist) induced opposite effect in trained rats. These results show that exercise training induces a differential RVLM responsiveness to Ang peptides, which was corroborated by the selective antagonists, indicating that the RVLM is a site in the central nervous system involved in the adaptive mechanisms triggered during exercise training.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1040, Issues 1â2, 8 April 2005, Pages 121-128
Journal: Brain Research - Volume 1040, Issues 1â2, 8 April 2005, Pages 121-128
نویسندگان
Lenice K. Becker, Robson A.S. Santos, Maria José Campagnole-Santos,