کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416690 | 1614340 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dual effects of the lichen glucan PB-2, extracted from Flavoparmelia baltimorensis, on the induction of long-term potentiation in the dentate gyrus of the anesthetized rat: possible mediation via adrenaline β- and interleukin-1 receptors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We have previously found that oral or intravenous (i.v.) administration of the polysaccharide fraction PB-2, extracted from the lichen Flavoparmelia baltimorensis, facilitated the induction of long-term potentiation (LTP) in the dentate gyrus (DG) in vivo. In this study, the mechanism underlying the effect of PB-2 on the induction of LTP was investigated in the DG of anesthetized rat focusing on the contribution of the interleukin-1 (IL-1) receptor and the adrenaline β-receptor. An i.v. injection of IL-1ra (10â9 g/kg), an antagonist of the IL-1 receptor, had no effect on the basal response in the DG; however, this treatment augmented the enhancement of LTP induced by a single i.v. injection of PB-2 (10â3 g/kg). This potentiating effect was also observed following intracerebroventricular (i.c.v.) injection of IL-1ra (10â15-10â11 g). An i.v. injection of IL-1β (3.5Ã10â15-3.5Ã10â9 g/kg) inhibited the induction of LTP, which was diminished by the previous application of IL-1ra. These results suggest that the activation of the IL-1 receptor induces the suppression of LTP in PB-2-treated rats, and that endogenous IL-1β contributes to the IL-1 receptor activation. An i.c.v. infusion of metoprolol (7.5 à 10â6 g), an antagonist of the adrenaline β1-receptor, attenuated the enhancement of LTP induced by an i.v. injection of PB-2. These results suggest that PB-2 has two different effects on the LTP, an enhancing effect and an inhibiting one, and that it exhibited the significant enhancing effect on the LTP as a total balance of these effects.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1032, Issues 1â2, 25 January 2005, Pages 183-192
Journal: Brain Research - Volume 1032, Issues 1â2, 25 January 2005, Pages 183-192
نویسندگان
Yoshikuni Edagawa, Fumiyuki Sato, Hiroshi Saito, Tadahiro Takeda, Noriko Shimizu, Takao Narui, Shoji Shibata, Yoshihisa Ito,