کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9416750 | 1292982 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Mitochondrial KATP channels in respiratory neurons and their role in the hypoxic facilitation of rhythmic activity
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
aCSF5-HDmKATPPBCmitochondrial KATP channelsPhorbol 12-myristate-13-acetateBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز PMA - LDC هاlong-term potentiation - تقویت درازمدتLTP - تقویت طولانی مدت یا LTP Excitable membranes and synaptic transmission - غشاء جذاب و انتقال سیناپسیartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیpre-Bötzinger complex - مجموعه پیش بتزینگرPostsynaptic mechanisms - مکانیزم های پست
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Hypoxia is damaging in neurons, but it can also produce beneficial effects by consolidating the activity of neural networks such as facilitation of respiratory activity [T.L. Baker-Herman, D.D. Fuller, R.W. Bavis, A.G. Zabka, F.J. Golder, N.J. Doperalski, R.A. Johnson, J.J. Watters, G.S. Mitchell, Nature Neuroscience 7 (2004) 48-55; J.L. Feldman, G.S. Mitchell, E.E. Nattie, Ann. Rev. Neurosci. 26 (2003) 239-266; D.M. Blitz, J.M. Ramirez, J. Neurophysiol. 87 (2002) 2964-2971]. The underlying mechanisms are unknown, and we hypothesized they may be similar to ischemic preconditioning in the heart, involving mitochondrial KATP (mKATP) channels. By measuring the mitochondrial potential (Ψm) and Ca2+ ([Ca2+]m) in neurons of pre-Bötzinger complex (pBC), we examined the functional expression of mKATP channels in the respiratory network. The opener of mKATP channels diazoxide decreased Ψm and [Ca2+]m both in pBC neurons and in isolated immobilized mitochondria. 5-Hydroxydecanoate (5-HD), the blocker of mKATP channels, increased both Ψm and [Ca2+]m. Phorbol 12-myristate-13-acetate (PMA) mimicked the effects of diazoxide. Protein kinase C (PKC) was stimulated during hypoxia that occurred mostly at the mitochondria. Brief hypoxia induced facilitation of the respiratory activity, which was prevented after blockade of mKATP channels with 5-HD and PKC with staurosporine. Diazoxide potentiated the motor output and subsequent application of hypoxia was ineffective. We propose that a PKC-induced stimulation of KATP channels in the mitochondria of respiratory neurons is responsible for the hypoxic facilitation of rhythmic activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1033, Issue 1, 1 February 2005, Pages 20-27
Journal: Brain Research - Volume 1033, Issue 1, 1 February 2005, Pages 20-27
نویسندگان
S.L. Mironov, N. Hartelt, M.V. Ivannikov,