کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
9416875 1292987 2005 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microinjections of SCH 23390 in the ventral tegmental area reduce operant responding under a progressive ratio schedule of food reinforcement in rats
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Microinjections of SCH 23390 in the ventral tegmental area reduce operant responding under a progressive ratio schedule of food reinforcement in rats
چکیده انگلیسی
We recently demonstrated that dopamine D1 receptors in the ventral tegmental area (VTA) are involved in intravenous cocaine reward. Here, we investigated whether VTA D1 receptors also are involved in food reward by testing the hypothesis that blockade of dopamine D1 receptors in the VTA attenuates the rewarding effects of food. Eighteen rats, with bilateral cannulae positioned to allow for microinjections in or just dorsal to the VTA, were trained to lever press under a progressive ratio schedule of reinforcement. After stable break points (BPs) were established, the rats received bilateral microinjections of SCH 23390, a D1 receptor antagonist. In Experiment 1, where the reward consisted of 1 food pellet, injections of SCH 23390 (0, 1, 2, or 4 μg/0.5 μl) in the VTA (N = 9) significantly decreased BPs (P < 0.001), while bilateral microinjections dorsal to the VTA (N = 9) did not. In Experiment 2 (N = 6), where the reward consisted of 1 or 2 food pellets, intra-VTA injections of SCH 23390 (0 and 4 μg/0.5 μl) decreased BPs at the 1 food pellet level (P < 0.05), but not at the 2 food pellet level. Thus, the data showed that intra-VTA microinjections of SCH 23390 reduced the rewarding effects of food. This effect was surmountable by increasing food reward, ruling out motoric effects, and did not occur when injections were made dorsal to VTA, eliminating the possibility that the effect was caused by the dorsal diffusion of drug. These data suggest that dendritically released dopamine in the VTA plays a significant role in food reward.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1033, Issue 2, 8 February 2005, Pages 179-185
نویسندگان
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