کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9422675 | 1614465 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory
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کلمات کلیدی
Novelty preference - اولویت نوآوریSpatial memory - حافظه فضاییEpisodic-like memory - حافظه پراکنده مانندprefrontal cortex - قشر prefrontalNeural Basis of Behavior - مبانی عصبی رفتاریHippocampus - هیپوکامپ Learning and memory: systems and functions—animals - یادگیری و حافظه: سیستم ها و توابع - حیوانات
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory Episodic-like memory in mice: Simultaneous assessment of object, place and temporal order memory](/preview/png/9422675.png)
چکیده انگلیسی
We designed a three-trial “what”,-“where”-and-“when” object exploration task in which different versions of the novelty preference paradigm were combined to subsume (a) object recognition memory, (b) the memory for locations in which objects were explored and (c) the temporal order memory for objects presented at distinct time points. Our results suggest that mice are able to (a) recognize previously explored objects, (b) remember the location in which particular objects were previously encountered and (c) discriminate the relative recency in which different objects were presented. We suggest that our protocol providing the simultaneous assessment of object memory for “what”,-“where”-and-“when” in mice might be useful in the search for the neural substrates of episodic memory, the screening for promnestic drugs and the behavioral phenotyping of genetic models of neuropsychiatric diseases affecting episodic memory.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Protocols - Volume 16, Issues 1â3, December 2005, Pages 10-19
Journal: Brain Research Protocols - Volume 16, Issues 1â3, December 2005, Pages 10-19
نویسندگان
Ekrem Dere, Joseph P. Huston, Maria A. De Souza Silva,