کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9423169 | 1294778 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Thyroid hormone and remyelination in adult central nervous system: a lesson from an inflammatory-demyelinating disease
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کلمات کلیدی
Remyelination - Remyelinimasexperimental allergic encephalomyelitis - آنسفالومیلیت آلرژیک تجربیCell differentiation and migration - تمایز سلولی و مهاجرتDevelopment and regeneration - توسعه و بازسازیoligodendrocyte precursor cell - سلول پیش سلول oligodendrocyteNeural stem cells - سلولهای بنیادی عصبیThyroid hormone - هورمون تیروئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Re-myelination in the adult CNS has been demonstrated in different experimental models of demyelinating diseases. However, there is no clear evidence that re-myelination is effective in multiple sclerosis (MS), the most diffuse demyelinating disease. Moreover, chronic disabilities in MS are believed to be due to remyelination failure and consequent neuron damage and degeneration. Due to the presence of numerous oligodendrocyte precursors inside demyelination plaques, reasons for remyelination failure are unknown. In this paper, we reviewed data from embryonic development and in vitro studies supporting the primary role of thyroid hormone in oligodendrocyte maturation. We also reviewed personal data on the possibility of promoting myelination in chronic experimental allergic encephalomyelitis (EAE), a widely used experimental model of MS, by recruiting progenitors and channeling them into oligodendroglial lineage through the administration of thyroid hormone.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Reviews - Volume 48, Issue 2, April 2005, Pages 339-346
Journal: Brain Research Reviews - Volume 48, Issue 2, April 2005, Pages 339-346
نویسندگان
Laura Calzà , Mercedes Fernandez, Alessandro Giuliani, Giulia D'Intino, Stefania Pirondi, Sandra Sivilia, Michela Paradisi, Nadia DeSordi, Luciana Giardino,