کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425454 | 1295874 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Physiological control of emotion-related behaviors by endogenous enkephalins involves essentially the delta opioid receptors
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کلمات کلیدی
MORAPNRB 101Aminopeptidase N - آمینوپپتیداز NAntidepressant-like effects - اثرات ضد افسردگی مانندAnxiety - اضطرابNeutral endopeptidase - اندوپپتیداز عصبیanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of varianceKnockout animals - حیوانات نابودAntinociception - ضد انعقادMice - موشNEP - نپMu opioid receptor - گیرنده اپیدمی م
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The endogenous pentapeptide enkephalins bind to the mu and delta opioid receptors, with a slightly higher affinity for the latter. It remains a controversy regarding the respective physiological role of mu and delta opioid receptors in the control of emotion and motivation. One of the difficulties to investigate this problem is the low tonic extracellular release of enkephalins in various brain structures. To overcome this problem the synaptic levels of these pentapeptides were enhanced by inhibition of enzymes involved in their catabolism with the selective inhibitor H3N-CH(CH2-CH2-S-CH3)-CH2-S-S-CH2-CH(CH2Ï)-CONH-CH(CH2Ï)-COOCH2Ï (RB101). This compound was shown to increase the extracellular levels and lifetime of endogenous enkephalins. Similar responses were obtained in wild-type and mu opioid receptor knockout mice following RB 101 administration in behavioral tests measuring locomotor activity, anxiety (elevated O-maze), and motivation (forced swim test and conditioned suppression of motility). In contrast, RB 101 led to antinociceptive responses only in wild-type animals using hot plate and tail immersion tests. These results clearly demonstrate the critical role of delta opioid receptors activated by the endogenous opioid peptides, in the physiological control of emotion- and motivation-related behaviors. In contrast, antinociceptive modulation, at least with respect to thermal nociceptive stimuli, involves enkephalin-activated mu opioid receptors. These findings could open new perspectives in the treatment of mood disorders using either inhibitors of enkephalin catabolism or delta opioid agonists.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 135, Issue 2, 2005, Pages 305-313
Journal: Neuroscience - Volume 135, Issue 2, 2005, Pages 305-313
نویسندگان
M. Mas Nieto, S.L.E. Guen, B.L. Kieffer, B.P. Roques, F. Noble,