کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425520 | 1295877 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Developmental changes in the spatio-temporal pattern of respiratory neuron activity in the medulla of late fetal rat
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کلمات کلیدی
aCSFpFRGI–V - I - VOptical imaging - تصویربرداری نوریcurrent-voltage - جریان ولتاژFetal rat - جنین جنینIn vitro - درونکشتگاهیvoltage-sensitive dye - رنگ حساس به ولتاژembryonic day - روز جنینیRespiratory rhythm - ریتم تنفسیlucifer yellow - لوسیفر زردartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیVentral medulla - مدولال شکمی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
We investigated how the spatio-temporal pattern of respiratory neuron network activity in the ventral medulla changes during the late fetal period of rat. Brainstem-spinal cord preparations isolated from rat fetuses on embryonic days 17-21 (E17-E21) were stained with a voltage-sensitive dye for optical image analysis of neuronal activity of the ventral medulla. The spatio-temporal pattern of respiratory neuron activity in the preparation from E20 to E21 was basically identical to that of neonatal rat; pre-inspiratory activity in a limited region of the rostral ventrolateral medulla, the para-facial region, preceded by several hundred milliseconds the onset of inspiratory activity in the more caudal ventrolateral medulla, the pre-Bötzinger complex level. In contrast, in E17-E18 specimens, pre-inspiratory activity could not be detected in the rostral medulla at the level of the facial nucleus. Neuronal activity appeared to begin at the pre-Bötzinger complex level shortly before onset of the inspiratory burst. Strong activity then developed in the facial nucleus and peaked in the post-inspiratory phase. The transition of these patterns of respiratory activity occurred at E19. We conclude that the changes in the spatio-temporal pattern of neuronal activity reflect developmental changes in the cellular elements underlying rhythm generation in the fetal respiratory neuron network. We suggest that the pre-inspiratory neuron network of the para-facial region in the rostral ventrolateral medulla functions as the rhythm generator after E19/20.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 131, Issue 4, 2005, Pages 969-977
Journal: Neuroscience - Volume 131, Issue 4, 2005, Pages 969-977
نویسندگان
H. Onimaru, I. Homma,