کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425583 | 1295880 | 2005 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Unilateral cochlear ablation in adult ferrets results in upregulation in calretinin immunostaining in the central nucleus of the inferior colliculus
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کلمات کلیدی
CNICDCICECICHearing loss - از دست دادن شنواییAdulthood - بزرگسالانQuantitative image analysis - تجزیه و تحلیل تصویر کمیexternal cortex of the inferior colliculus - قشر خارجی کولیکولوس پایینdorsal cortex of the inferior colliculus - قشر پشتی کولیکولوس پایینCentral Nucleus of the Inferior Colliculus - هسته مرکزی کولیکولوس پایینcalcium-binding protein - پروتئین متصل به کلسیمPlasticity - پلاستیکCalretinin - کالورتینینInferior colliculus - کولیکولوس پایین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In the present study, unilateral cochlear ablations were performed in adult ferrets in order to determine whether an upregulation of the calretinin immunostained plexus in the central nucleus of the inferior colliculus occurs and if so, what the time course of this upregulation is. Accordingly, the mean gray level and the calretinin-immunostained area of the axonal plexus in the central nucleus of the inferior colliculus were evaluated at 1, 20 and 90 days after cochlear ablation. In unoperated animals, the calretinin-immunostained plexus was bilaterally symmetric. In ablated animals, both the mean gray level and the immunostained area of the plexus increased in the central nucleus of the inferior colliculus contralateral to the lesion compared with both the ipsilateral side and unoperated animals. This upregulation was present 24 h after the ablation and did not change at the two subsequent time points. In a previous study in young ferrets, the immunostained area of the plexus in the central nucleus of the inferior colliculus contralateral to the lesion increased 200% compared with control ferrets [J Comp Neurol 460 (2003) 585], whereas it increased only 33% in adult ferrets. These findings suggest that 1) calretinin upregulation in the contralateral central nucleus of the inferior colliculus following cochlear ablation occurs by 24 h after cochlear ablation and 2) there is an age-related decline in the magnitude of this upregulation after cochlear ablation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 136, Issue 3, 2005, Pages 957-969
Journal: Neuroscience - Volume 136, Issue 3, 2005, Pages 957-969
نویسندگان
J.C. Alvarado, V. Fuentes-Santamaria, S.R. Franklin, J.K. Brunso-Bechtold, C.K. Henkel,