کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9425631 | 1295883 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cocaine- and amphetamine-regulated transcript in the nucleus accumbens participates in the regulation of feeding behavior in rats
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کلمات کلیدی
intracerebroventricularPVHAcbShFluorogoldCARTi.c.v.aCSFPEFRODAcb - ACBImmunoreactivity - ایمنی فعالanalysis of variance - تحلیل واریانسANOVA - تحلیل واریانس Analysis of variancecocaine- and amphetamine-regulated transcript - دستورالعمل تنظیم شده کوکائین و آمفتامینLocomotor activity - فعالیت locomotorArc - قوسartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیfood intake - مصرف غذاmuscimol - موسیمول Nucleus accumbens - هسته accumbensarcuate nucleus - هسته قوسparaventricular nucleus of the hypothalamus - هسته پروانه مرکزی هیپوتالاموسbody weight - وزن بدنGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The present studies aimed to determine whether cocaine- and amphetamine-regulated transcript (CART) peptide in the nucleus of accumbens shell (AcbSh) is implicated in the regulation of food intake. Bilateral intranuclear injections of CART peptide (55-102, 1μg/μl/side) into the AcbSh decreased food intake with no change in locomotion activity and attenuated the orexigenic effect of the GABAA agonist muscimol (100 ng/μl/side) in male Sprague-Dawley rats. Decreased food intake after bilateral intranuclear injections of CART was more sustained in freely fed rats than in food-deprived rats, suggesting fuel availability is an important factor in modulating the function of CART in the regulation of feeding. Our anatomical findings indicate that in addition to the perifornical region and the arcuate nucleus, some neurons within the AcbSh also project within the AcbSh. Moreover, many of these efferent cells contain CART immunoreactivity, including those which reside within the AcbSh, suggesting that accumbal CART circuitry is involved in the central function of the nucleus accumbens. Furthermore, fasting suppressed CART mRNA levels in the AcbSh, paraventricular nucleus of the hypothalamus, arcuate nucleus, and the perifornical region, indicating that the Acb is sensitive to fuel availability to an extent similar to those regions in the hypothalamus. Our findings are the first to demonstrate that CART mRNA in the AcbSh is sensitive to metabolic challenges and that injection of CART peptide into the AcbSh has an inhibitory effect on food intake.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 133, Issue 3, 2005, Pages 841-851
Journal: Neuroscience - Volume 133, Issue 3, 2005, Pages 841-851
نویسندگان
S.-C. Yang, K.-R. Shieh, H.-Y. Li,